Rabbit Polyclonal CEP76 Antibody

The CEP76 antibody is a research tool designed to target the Centrosomal Protein 76 (CEP76), a key component involved in centriole duplication and centrosome function. CEP76 is a conserved protein localized to the centrosome, a critical microtubule-organizing center essential for cell division, mitotic spindle formation, and genomic stability. Studies have linked CEP76 to the regulation of centriole duplication, ensuring proper cell cycle progression by preventing overduplication. Dysregulation of CEP76 has been implicated in mitotic errors, chromosomal instability, and diseases such as microcephaly or cancer. The antibody is commonly used in techniques like immunofluorescence, Western blotting, or immunoprecipitation to visualize CEP76's subcellular localization, assess expression levels, or study its interactions with other centrosomal proteins (e.g., CEP63. CEP152). Its development has facilitated investigations into centrosome biology, cell cycle checkpoints, and mechanisms underlying centrosome-related pathologies. Commercial CEP76 antibodies are typically raised in rabbits or mice, validated for specificity using knockout cell lines, and cited in studies exploring centrosome amplification or ciliogenesis. Ongoing research aims to clarify its precise molecular roles and therapeutic potential in diseases linked to centrosomal defects.