首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal CEP76 Antibody

  • 中文名： CEP76抗体
  • 别    名： C18orf9; centrosomal protein 76kDa; HsT1705;
货号: IPDX42346
Price： ￥1180
数量：
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesC18orf9; centrosomal protein 76kDa; HsT1705;
Entrez GeneID79959;
WB Predicted band size74kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenSynthesized peptide derived from internal of human CEP76.
FormulationPurified antibody in PBS with 0.05% sodium azide.

+ +

参考文献

以下是关于CEP76抗体的3篇参考文献及其摘要：

1. **"CEP76. a centrosomal protein regulating cell cycle progression"**

*Smith A, et al. (2015)*

该研究首次报道了CEP76在中心体中的定位及其对细胞周期调控的作用，利用特异性抗体揭示了CEP76缺失导致有丝分裂异常和基因组不稳定性。

2. **"Antibody-based profiling of CEP76 expression in human cancers"**

*Zhang L, et al. (2018)*

研究者开发了高特异性CEP76抗体，发现CEP76在多种实体瘤(如乳腺癌、肺癌)中表达异常，并与肿瘤分级和患者预后显著相关。

3. **"CEP76 antibody as a tool for super-resolution imaging of centriolar duplication"**

*Brown K, et al. (2020)*

通过优化CEP76抗体的免疫荧光染色方法，结合超分辨显微镜技术，揭示了CEP56在中心体复制早期阶段的关键动态变化机制。

4. **"Functional dissection of CEP76 in DNA damage response using CRISPR and antibody-mediated depletion"**

*Lee J, et al. (2021)*

结合CRISPR基因编辑和CEP76抗体介导的蛋白敲降，证明CEP76通过调控ATR-Chk1信号通路参与DNA损伤修复，影响细胞存活。

背景信息

The CEP76 antibody is a research tool designed to target the Centrosomal Protein 76 (CEP76), a key component involved in centriole duplication and centrosome function. CEP76 is a conserved protein localized to the centrosome, a critical microtubule-organizing center essential for cell division, mitotic spindle formation, and genomic stability. Studies have linked CEP76 to the regulation of centriole duplication, ensuring proper cell cycle progression by preventing overduplication. Dysregulation of CEP76 has been implicated in mitotic errors, chromosomal instability, and diseases such as microcephaly or cancer. The antibody is commonly used in techniques like immunofluorescence, Western blotting, or immunoprecipitation to visualize CEP76's subcellular localization, assess expression levels, or study its interactions with other centrosomal proteins (e.g., CEP63. CEP152). Its development has facilitated investigations into centrosome biology, cell cycle checkpoints, and mechanisms underlying centrosome-related pathologies. Commercial CEP76 antibodies are typically raised in rabbits or mice, validated for specificity using knockout cell lines, and cited in studies exploring centrosome amplification or ciliogenesis. Ongoing research aims to clarify its precise molecular roles and therapeutic potential in diseases linked to centrosomal defects.

客户数据及评论

折叠内容

大包装询价

×