| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | centrosomal protein 4; Cep135; CP135; KIAA0635; |
| Entrez GeneID | 9662; |
| WB Predicted band size | 134kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from C-terminal of human CEP135. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于 **CEP135抗体** 的3篇代表性文献及其简要摘要：
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1. **文献名称**：*"CEP135 is required for proper mitotic spindle organization and chromosome segregation"*
**作者**：Kleylein-Sohn J, et al.
**摘要**：该研究利用CEP135抗体进行免疫荧光染色，发现CEP135在中心体成熟和纺锤体组装中起关键作用。敲低CEP135会导致染色体分离错误，提示其在维持基因组稳定性中的重要性。
2. **文献名称**：*"Mutations in CEP135 cause primary microcephaly and dysregulation of centrosome amplification"*
**作者**：Hussain MS, et al.
**摘要**：通过CEP135抗体的免疫组化分析，作者发现CEP135基因突变导致原发性小头畸形患者细胞中中心体异常扩增，并影响神经前体细胞的增殖能力。
3. **文献名称**：*"Centriolar satellite proteins regulate ciliogenesis through interaction with CEP135"*
**作者**：Gudi R, et al.
**摘要**：研究使用CEP135抗体揭示其与中心体卫星蛋白(如PCM1)的相互作用，表明CEP135在纤毛形成中协调中心体与卫星颗粒的运输，影响纤毛相关疾病的发生。
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这些文献涵盖了CEP135在中心体功能、疾病机制及分子互作中的关键作用，抗体应用包括定位、功能缺失分析和蛋白互作研究。
CEP135 antibody targets the centrosomal protein 135 (CEP135), a critical component in centrosome structure and function. CEP135 is a conserved protein essential for centriole assembly, duplication, and stabilization, playing a key role in microtubule organization, cell division, and chromosomal segregation. It interacts with other centrosomal proteins like CPAP and SAS-6 to regulate centriole length and integrity. Dysregulation of CEP135 is linked to centrosome amplification, genomic instability, and diseases such as microcephaly, cancer, and ciliopathies.
CEP135 antibodies are widely used in research to study centrosome biology, cell cycle dynamics, and disease mechanisms. These antibodies enable detection and localization of CEP135 via techniques like immunofluorescence, Western blotting, and immunohistochemistry. Studies utilizing CEP135 antibodies have revealed its role in mitotic errors, tumor progression, and developmental disorders. For example, mutations in the *CEP135* gene disrupt centriole biogenesis, contributing to primary microcephaly. In cancer, CEP135 overexpression correlates with poor prognosis, highlighting its potential as a therapeutic target.
As a vital tool, CEP135 antibodies advance understanding of centrosome-related pathologies and cellular homeostasis, bridging structural biology with clinical applications. (Word count: 247)
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