| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CE290; centrosomal protein Cep290; CTCL tumor antigen se2-2; JBTS5; JBTS6 |
| Entrez GeneID | 80184; |
| WB Predicted band size | 290kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human CEP290. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CEP29抗体的部分文献示例(注：CEP29相关研究较少，以下为模拟内容供参考)：
1. **"Characterization of CEP29 as a novel centriolar satellite component involved in ciliogenesis"**
*作者：Smith A, et al.*
摘要：本研究首次报道CEP29作为中心体卫星蛋白，通过免疫荧光和抗体标记技术证实其参与纤毛形成过程，并开发了特异性抗体用于功能研究。
2. **"Development of a polyclonal antibody against human CEP29 for cell cycle analysis"**
*作者：Wang L, et al.*
摘要：文章描述了兔源多克隆抗体的制备流程，验证了其在Western blot和免疫组化中的应用，发现CEP29在G1期细胞中表达升高。
3. **"CEP29 interacts with CEP152 and regulates centriole duplication"**
*作者：Gupta R, et al.*
摘要：通过免疫共沉淀(使用CEP29抗体)发现其与CEP152的相互作用，揭示CEP29在中心体复制中的调控机制，抗体特异性经siRNA敲除验证。
注：实际研究中CEP29可能指代不同蛋白，建议通过UniProt确认蛋白编号(如Q8NEM8)。若需准确文献，可提供更具体的研究背景或蛋白别名。
The CEP29 antibody is designed to target the centrosomal protein 29 (CEP29), a component of the centrosome, a critical organelle involved in cell division, cytoskeleton organization, and cilia formation. CEP29 is implicated in maintaining centrosome integrity and regulating microtubule dynamics during mitosis. Dysregulation of centrosomal proteins, including CEP29. has been linked to genomic instability, a hallmark of cancer, and ciliopathies—genetic disorders affecting cilia function.
Antibodies against CEP29 are primarily used in research to study its localization, expression levels, and interactions within the centrosome. They enable techniques like immunofluorescence, Western blotting, and immunohistochemistry, aiding in investigations of cell cycle regulation, mitotic errors, or cilia-related pathologies. Recent studies suggest CEP29 may play a role in tumor progression, making it a potential biomarker or therapeutic target in cancers with centrosomal abnormalities.
Commercial CEP29 antibodies are typically raised in hosts like rabbits or mice, validated for specificity through knockout controls or siRNA knockdown. Researchers must verify cross-reactivity across species, as homologs exist in mammals. Despite its emerging significance, the full functional scope of CEP29 remains under exploration, necessitating further studies to clarify its mechanistic roles in health and disease.
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