| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cell growth regulator with EF hand domain protein 1; Cell growth regulatory gene 11 protein; |
| Entrez GeneID | 10669; |
| WB Predicted band size | 31kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from C-internal of human CGREF1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CGREF1抗体的参考文献示例(注：以下内容为模拟虚构，仅供参考格式)：
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1. **文献名称**：*CGREF1 Antibody Validation and Its Role in Neural Stem Cell Differentiation*
**作者**：Lee J, et al.
**摘要**：本研究验证了兔源多克隆CGREF1抗体的特异性，通过Western blot和免疫荧光证实其在神经干细胞中的表达。结果显示CGREF1通过调控Wnt信号通路促进神经元分化。
2. **文献名称**：*Expression Profiling of CGREF1 in Colorectal Cancer Using Immunohistochemistry*
**作者**：Gomez-Rivera F, et al.
**摘要**：利用CGREF1抗体对结直肠癌组织进行免疫组化分析，发现CGREF1在肿瘤边缘高表达，并与患者预后不良相关，提示其作为癌症生物标志物的潜力。
3. **文献名称**：*CGREF1 Knockdown and Overexpression Studies in Zebrafish Embryos*
**作者**：Wang Y, et al.
**摘要**：通过抗CGREF1抗体进行原位杂交和蛋白质定位，结合基因编辑技术，揭示CGREF1在斑马鱼早期胚胎发育中对体节形成的调控作用。
4. **文献名称**：*CGREF1 Interaction Network Revealed by Co-Immunoprecipitation*
**作者**：Singh R, et al.
**摘要**：采用CGREF1抗体进行免疫共沉淀实验，鉴定了其与细胞骨架蛋白的相互作用，表明CGREF1在细胞迁移和粘附中的功能。
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**注**：以上文献为示例性质，实际研究中请通过学术数据库(如PubMed、Web of Science)检索真实发表的论文。
The CGREF1 antibody targets the Cell Growth Regulator with EF-Hand domain 1 (CGREF1) protein, a conserved molecule implicated in cellular growth regulation, tissue development, and stress responses. CGREF1 contains an EF-hand calcium-binding domain, suggesting potential roles in calcium signaling pathways. It is highly expressed in the brain, kidneys, and reproductive organs, and studies link it to neural development, synaptic plasticity, and tumorigenesis. For instance, CGREF1 downregulation has been observed in certain cancers, correlating with poor prognosis, while its overexpression may inhibit cancer cell proliferation.
The CGREF1 antibody is widely used in research to detect protein expression via techniques like Western blotting, immunohistochemistry, and immunofluorescence. It aids in exploring CGREF1's interaction networks, post-translational modifications, and tissue-specific functions. Commercial CGREF1 antibodies are typically raised in rabbits or mice, with validation in knockout models to ensure specificity. Recent studies also investigate its role in neurodegenerative diseases and metabolic disorders, highlighting its therapeutic potential. Despite progress, the precise molecular mechanisms of CGREF1 remain understudied, necessitating further research to clarify its physiological and pathological significance.
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