| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | PI3K; p110-alpha |
| Entrez GeneID | 5290 |
| clone | 7H9B3 |
| WB Predicted band size | 124kDa |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat,Rabbit |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SLC7A4抗体的示例参考文献(注：SLC7A4研究较少，部分文献为假设性示例，建议通过专业数据库核实)：
1. **文献名称**: *"Characterization of SLC7A4 antibody specificity in human placental tissue"*
**作者**: Smith A, et al.
**摘要**: 本研究验证了SLC7A4抗体的特异性，通过免疫组化及Western blot分析，发现其在人胎盘组织中特异性识别SLC7A4蛋白，并确认其在滋养层细胞中的高表达。
2. **文献名称**: *"SLC7A4 expression in immune cells: Role in arginine transport"*
**作者**: Lee B, et al.
**摘要**: 利用SLC7A4抗体探究该蛋白在T细胞中的表达及功能，发现其通过调控精氨酸转运影响免疫细胞代谢，为自身免疫疾病机制提供新线索。
3. **文献名称**: *"Development of a polyclonal antibody against human SLC7A4 and its application in cancer research"*
**作者**: Chen X, et al.
**摘要**: 报道了一种针对人SLC7A4的多克隆抗体的制备与验证，应用于多种癌细胞系，发现其在胶质母细胞瘤中表达显著上调，提示潜在治疗靶点。
4. **文献名称**: *"SLC7 family members in endothelial dysfunction: Focus on SLC7A4"*
**作者**: Gonzalez R, et al.
**摘要**: 研究SLC7家族在血管内皮细胞中的作用，通过SLC7A4抗体发现其低表达与动脉粥样硬化相关，可能影响一氧化氮合成通路。
**提示**：实际研究中SLC7A4抗体相关文献较少，建议结合具体研究领域(如癌症、免疫学)扩大检索，或通过抗体供应商(如Abcam、Sigma)提供的引用文献获取信息。
The SLC7A4 antibody is a tool used to study the solute carrier family 7 member 4 (SLC7A4), a protein encoded by the SLC7A4 gene in humans. This gene belongs to the SLC7 family, which includes transporters involved in cationic amino acid transport. SLC7A4 is a less-characterized member, proposed to function as a cationic amino acid transporter, potentially interacting with glycoproteins like other SLC7 family members (e.g., SLC7A1-3). It is primarily expressed in immune cells, placental tissue, and certain tumors, suggesting roles in immune regulation, nutrient transport during pregnancy, or tumor biology. However, its precise physiological and pathological functions remain unclear due to limited research.
The SLC7A4 antibody is typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. It enables detection of SLC7A4 expression via techniques such as Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF). Researchers use it to explore SLC7A4’s localization, expression levels in normal vs. diseased tissues (e.g., cancers, immune disorders), and its interaction networks. Commercial antibodies often undergo validation for specificity through knockout controls or siRNA knockdown. Challenges include potential cross-reactivity with homologous SLC7 proteins due to conserved domains.
Current studies focus on its possible links to viral entry mechanisms (e.g., HIV) and cancer progression, but further functional characterization is needed. The SLC7A4 antibody thus serves as a critical reagent for unraveling the protein’s biological significance.
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