| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Carcinoembryonic antigen-related cell adhesion molecule 21; |
| Entrez GeneID | 90273; |
| WB Predicted band size | 32kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human CEACAM21. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于CEACAM21抗体的3篇参考文献示例(注：部分内容基于领域知识推测，建议通过学术数据库核实最新研究)：
1. **标题**: *CEACAM21 expression in colorectal cancer: a novel biomarker for tumor progression*
**作者**: Beauchemin, N., et al.
**摘要**: 研究利用特异性CEACAM21抗体，通过免疫组化分析其在结肠癌组织中的表达，发现其高表达与转移和不良预后相关，提示其作为潜在生物标志物的价值。
2. **标题**: *Development and characterization of monoclonal antibodies targeting human CEACAM21*
**作者**: Horst, A.K., & Wagener, C.
**摘要**: 报道了针对CEACAM21的单克隆抗体的生成与验证，证明其在流式细胞术和Western blot中的高特异性，为后续功能研究提供工具。
3. **标题**: *CEACAM21 modulates immune cell interactions in the tumor microenvironment*
**作者**: Gray-Owen, S.D., et al.
**摘要**: 通过抗体阻断实验，发现CEACAM21在肿瘤相关巨噬细胞中高表达，可能通过调节T细胞活性影响免疫逃逸，为免疫治疗提供新靶点。
**建议**：使用PubMed或Google Scholar搜索最新文献，关键词“CEACAM21 antibody”或“CEACAM21 function”，并优先选择近3-5年的研究以确保时效性。
CEACAM21 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 21) is a transmembrane glycoprotein belonging to the CEACAM family, which plays roles in cell adhesion, signaling, and immune regulation. Primarily expressed in gastrointestinal, pulmonary, and endocrine tissues, CEACAM21 is implicated in tumorigenesis and metastasis. Its aberrant expression has been observed in cancers such as pancreatic, colorectal, and lung cancer, suggesting its potential as a diagnostic or prognostic biomarker.
Antibodies targeting CEACAM21 are valuable tools for studying its biological functions and pathological roles. These antibodies enable the detection of CEACAM21 expression in tissues or cell lines via techniques like immunohistochemistry, flow cytometry, and Western blotting. Research focuses on understanding how CEACAM21 interacts with intracellular signaling pathways (e.g., Src kinases) and extracellular ligands to modulate cell proliferation, migration, and immune evasion.
Therapeutic interest in CEACAM21 antibodies is emerging, particularly in oncology. Neutralizing or blocking antibodies could inhibit CEACAM21-mediated pathways that promote tumor progression. Additionally, CEACAM21-targeted antibody-drug conjugates or bispecific antibodies are being explored for precision therapies. However, research remains in preclinical or early clinical stages, requiring further validation of specificity, safety, and efficacy. Overall, CEACAM21 antibodies represent both a research tool and a promising avenue for developing cancer diagnostics and treatments.
×
