首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal CA13 Antibody

  • 中文名: CA13抗体
  • 别    名: CA-XIII; CAH13; carbonate dehydratase XIII; carbonic anhydrase 13; carbonic anhydrase XIII
货号: IPDX42333
Price: ¥1180
数量:
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCA-XIII; CAH13; carbonate dehydratase XIII; carbonic anhydrase 13; carbonic anhydrase XIII
Entrez GeneID377677;
WB Predicted band size35kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthesized peptide derived from internal of human CA13.
FormulationPurified antibody in PBS with 0.05% sodium azide.

+ +

参考文献

以下是关于CA13抗体的模拟参考文献示例(请注意这些文献为虚构示例,建议通过学术数据库查询真实研究):

---

1. **文献名称**: "Monoclonal Antibody Development for Carbonic Anhydrase XIII: Applications in pH Regulation Studies"

**作者**: Garcia, L., et al.

**摘要**: 本研究开发了一种针对CA13的单克隆抗体,并验证其在细胞pH调节中的功能。通过免疫印迹和免疫荧光实验,证明该抗体可特异性识别CA13蛋白,为研究其在代谢性疾病中的作用提供了工具。

2. **文献名称**: "CA13 as a Novel Biomarker in Lung Adenocarcinoma: Validation via Immunohistochemical Staining"

**作者**: Smith, J., et al.

**摘要**: 利用CA13抗体对肺癌组织进行免疫组化分析,发现CA13在腺癌中高表达,且与患者预后相关。研究支持CA13作为潜在诊断标志物的价值。

3. **文献名称**: "Structural Characterization of Carbonic Anhydrase XIII Using Polyclonal Antibodies"

**作者**: Johnson, R., et al.

**摘要**: 通过制备CA13多克隆抗体,解析其在肾脏和脑组织中的分布,结合X射线晶体学揭示CA13的活性位点结构,为药物靶点研究奠定基础。

4. **文献名称**: "CA13 Antibody-Based Detection in Ovarian Cancer Serum Samples"

**作者**: Lee, H., et al.

**摘要**: 开发了一种基于CA13抗体的ELISA检测方法,用于卵巢癌患者血清筛查。结果显示CA13水平与肿瘤进展呈正相关,提示其作为无创诊断工具的潜力。

---

建议通过 **PubMed**、**Web of Science** 或 **Google Scholar** 检索真实文献,关键词如“Carbonic Anhydrase 13 antibody”或“CA13 biomarker”。

背景信息

**Background of CA13 Antibody**

CA13 (Carbonic Anhydrase XIII) is a member of the carbonic anhydrase enzyme family, which plays critical roles in pH regulation, CO₂ transport, and ion balance. The CA13 gene encodes a cytosolic enzyme predominantly expressed in specific tissues, including the thyroid, salivary glands, and respiratory tract. Unlike other carbonic anhydrases, CA13 exhibits unique structural and functional characteristics, such as lower catalytic efficiency, suggesting specialized physiological roles.

Antibodies targeting CA13 are valuable tools in biomedical research, enabling the detection and characterization of CA13 protein expression in tissues and cells. They are widely used in techniques like immunohistochemistry (IHC), Western blotting, and immunofluorescence to study CA13 distribution, overexpression, or dysregulation in diseases. For instance, altered CA13 levels have been implicated in certain cancers, including thyroid and lung malignancies, where it may influence tumor microenvironment acidity or cellular proliferation.

Additionally, CA13 antibodies contribute to understanding genetic disorders linked to carbonic anhydrase dysfunction, such as metabolic syndromes or respiratory conditions. Their specificity and reliability depend on epitope recognition and validation in experimental models. While therapeutic applications remain exploratory, CA13 antibodies hold potential as diagnostic markers or targets for modulating enzyme activity in disease contexts. Ongoing research continues to unravel CA13's precise biological functions and clinical relevance.

客户数据及评论

折叠内容

大包装询价

×