| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | DD3; DDX; HA1753; HAKRB; HAKRe; HSD17B5; KIAA0119; hluPGFS;;AKR1C3 |
| WB Predicted band size | 37 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human AKR1C3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于CLIP4抗体的参考文献示例(注：CLIP4相关研究较少，以下为假设性示例，建议通过学术数据库进一步验证)：
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1. **文献名称**: *CLIP4 regulates axonal transport through interaction with microtubules*
**作者**: Yamada, T. et al. (2010)
**摘要**: 本研究开发了针对CLIP4的多克隆抗体，证实其通过与微管相互作用调控神经元轴突的囊泡运输。抗体特异性通过敲低实验验证，并用于免疫荧光定位分析。
2. **文献名称**: *Characterization of CLIP family proteins in mitotic cells*
**作者**: Gupta, R. & Patel, S. (2013)
**摘要**: 比较CLIP1、CLIP2和CLIP4在细胞分裂中的功能差异，利用CLIP4抗体进行Western blot和免疫沉淀，揭示其在纺锤体组装中的作用。
3. **文献名称**: *Development of a polyclonal antibody for human CLIP4 and its application in cancer tissues*
**作者**: Smith, J. et al. (2015)
**摘要**: 描述针对人CLIP4抗原表位的多克隆抗体制备过程，验证其在不同癌症组织中的表达模式，提示CLIP4可能与肿瘤转移相关。
4. **文献名称**: *CLIP4 overexpression in breast cancer correlates with poor prognosis*
**作者**: Lee, H. et al. (2018)
**摘要**: 使用商业CLIP4抗体(Abcam #xxxxx)分析乳腺癌样本，发现CLIP4高表达与患者生存率下降相关，提示其作为潜在生物标志物。
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**注意**：上述文献为示例，实际研究中CLIP4可能涉及不同功能或名称(如“CAP-Gly linker protein 4”)。建议通过PubMed或Google Scholar以“CLIP4 antibody”、“CLIP4 function”等关键词检索最新文献，或查询抗体供应商(如Abcam、Sigma)的产品引用列表获取具体研究。
The CLIP4 antibody targets the CLIP4 protein (CAP-Gly domain-containing linker protein 4), a member of the CAMSAP/Patronin family involved in regulating microtubule organization and stability. CLIP4 plays a critical role in establishing non-centrosomal microtubule networks, particularly in polarized cells, by anchoring microtubule minus-ends to specific subcellular regions. This protein is essential for maintaining cell shape, intracellular transport, and cytoskeletal dynamics, with implications in neuronal development, epithelial polarity, and immune cell function.
The CLIP4 antibody is widely used in research to study microtubule-related processes through techniques like immunofluorescence, Western blotting, and immunoprecipitation. Its development has facilitated the exploration of CLIP4's interaction partners, post-translational modifications, and spatiotemporal localization in diverse cell types. Dysregulation of CLIP4 has been linked to pathological conditions, including neurodevelopmental disorders and cancer metastasis, making this antibody a valuable tool for mechanistic and diagnostic investigations.
Recent studies highlight CLIP4's role in cellular responses to mechanical stress and its crosstalk with actin cytoskeleton regulators, expanding its relevance in tissue homeostasis and disease. The antibody's specificity and reliability continue to support advances in understanding microtubule biology and its therapeutic applications.
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