Rabbit Polyclonal BRP16 Antibody

The BRP16 antibody is a well-characterized tool in Drosophila neurobiology, primarily used to study the Bruchpilot (BRP) protein, a key component of the active zone in presynaptic nerve terminals. BRP is essential for organizing T-bar structures at neuromuscular junctions, facilitating synaptic vesicle release and efficient neurotransmission. As a member of the CAST/ERC protein family conserved across species, BRP plays a critical role in synaptic architecture and function. The BRP16 antibody specifically recognizes an epitope within the N-terminal region of BRP, enabling researchers to visualize and quantify BRP distribution via immunohistochemistry, immunofluorescence, or Western blotting. Developed and validated in Drosophila models, this antibody has been instrumental in exploring synaptic development, plasticity, and pathology. Studies using BRP16 have linked BRP dysregulation to neurological defects, including impaired locomotion and memory, offering insights into mechanisms underlying neurodevelopmental and neurodegenerative disorders. Its application extends to electron microscopy studies, where it helps correlate molecular changes with ultrastructural synaptic alterations. Widely cited in fruit fly research, BRP16 remains a cornerstone for dissecting active zone biology and its implications for synaptic transmission.