Rabbit Polyclonal GUSBP1 Antibody

The GUSBP1 antibody targets the protein encoded by the *GUSBP1* (glucuronidase, beta pseudogene 1) gene, a processed pseudogene derived from the functional *GUSB* gene. *GUSB* encodes β-glucuronidase, a lysosomal enzyme involved in glycosaminoglycan degradation. Pseudogenes like *GUSBP1* are typically nonfunctional due to mutations but may retain sequence homology with their parent genes. Although *GUSBP1* is considered transcriptionally silent, emerging studies suggest potential roles in gene regulation, including acting as competitive endogenous RNAs (ceRNAs) or influencing chromatin remodeling. The GUSBP1 antibody is primarily used in research to investigate pseudogene expression, localization, and interactions, often via techniques like Western blotting, immunohistochemistry, or immunofluorescence. However, its utility is challenged by the pseudogene’s low expression levels and high homology with *GUSB*, necessitating stringent validation to ensure specificity. Studies employing this antibody aim to explore pseudogene-related mechanisms in diseases like cancer, where dysregulated pseudogenes may contribute to pathogenesis. Despite limited functional data, GUSBP1 remains of interest for understanding pseudogene biology and their potential regulatory roles in cellular processes.