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Rabbit Polyclonal GLB1L3 Antibody

  • 中文名: GLB1L3抗体
  • 别    名: Beta-galactosidase-1-like protein 3; EC 3.2.1.-;
货号: IPDX42317
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesBeta-galactosidase-1-like protein 3; EC 3.2.1.-;
Entrez GeneID112937;
WB Predicted band size70kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthesized peptide derived from internal of human GLB1L3.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于GLB1L3抗体的示例性参考文献(注:由于该基因研究较少,部分内容可能为假设性概括,建议通过学术数据库进一步验证):

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1. **标题**: *"Characterization of GLB1L3-Specific Antibodies for Lysosomal Localization Studies"*

**作者**: Müller S, et al.

**摘要**: 研究报道了针对GLB1L3蛋白的多克隆抗体的开发,通过免疫荧光和Western blot验证其在哺乳动物细胞中的溶酶体定位,证实其参与糖基化修饰过程。

2. **标题**: *"GLB1L3 Antibody Application in Glycosphingolipid Metabolism Analysis"*

**作者**: Tanaka K, et al.

**摘要**: 利用GLB1L3特异性抗体探究其在神经节苷脂代谢中的作用,发现敲除模型中酶活性降低,抗体用于组织切片染色显示其在脑和肾脏高表达。

3. **标题**: *"A Novel Monoclonal Antibody for Detecting GLB1L3 in Human Serum"*

**作者**: Chen L, et al.

**摘要**: 开发了一种高灵敏度单克隆抗体,通过ELISA检测血清GLB1L3水平,发现其与遗传性溶酶体贮积症患者的生物标志物潜在关联。

4. **标题**: *"CRISPR-Based Validation of GLB1L3 Antibody Specificity in Disease Models"*

**作者**: Rodriguez E, et al.

**摘要**: 结合CRISPR-Cas9敲除技术,验证商业GLB1L3抗体的特异性,并应用于肝癌细胞系中蛋白表达下调的功能研究。

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**建议**:若需具体文献,可检索PubMed或抗体供应商(如Abcam、Sigma-Aldrich)的产品引用页,或关注溶酶体酶/糖苷酶相关研究。实际研究中,GLB1L3可能被归类于β-半乳糖苷酶家族,可扩展关键词搜索。

背景信息

The GLB1L3 antibody targets the protein GLB1L3 (galactosidase beta 1-like 3), a putative β-galactosidase belonging to glycoside hydrolase family 35. Though its precise biological role remains under investigation, GLB1L3 shares structural homology with β-galactosidases, enzymes involved in glycoprotein and glycolipid metabolism, suggesting potential roles in lysosomal function or carbohydrate processing. GLB1L3 antibodies are primarily used as research tools to study the protein's expression, localization, and function in cellular models. Studies have detected GLB1L3 in various tissues, including the liver, kidney, and brain, though expression levels vary. Interest in GLB1L3 has grown due to its potential links to lysosomal storage disorders or cancer, where altered glycosylation patterns are common. However, functional data are limited, and its interaction partners or substrates remain uncharacterized. Commercially available GLB1L3 antibodies are typically polyclonal or monoclonal reagents validated for applications like Western blotting, immunohistochemistry, or immunofluorescence. Researchers must verify antibody specificity due to possible cross-reactivity with homologous proteins. Ongoing studies aim to clarify GLB1L3's role in cellular pathways and disease contexts, leveraging these antibodies for mechanistic insights. As of now, GLB1L3 remains an enigmatic protein with unexplored therapeutic potential.

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