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Rabbit Polyclonal BCL2L12 Antibody

  • 中文名: BCL2L12抗体
  • 别    名: Bcl-2-like protein 12; Bcl2-L-12; Bcl-2-related proline-rich protein;
货号: IPDX42308
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesBcl-2-like protein 12; Bcl2-L-12; Bcl-2-related proline-rich protein;
Entrez GeneID83596;
WB Predicted band size34kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthesized peptide derived from internal of human BCL2L12.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于BCL2L12抗体的3篇文献示例(注:文献信息为模拟生成,仅供参考):

1. **文献名称**:*BCL2L12在胶质母细胞瘤中的表达及预后价值*

**作者**:Papageorgiou et al.

**摘要**:通过免疫组化分析BCL2L12蛋白在胶质母细胞瘤组织中的表达,发现其高表达与患者生存期缩短显著相关,提示其可作为潜在预后标志物。

2. **文献名称**:*BCL2L12抗体在结直肠癌中的诊断应用研究*

**作者**:Stegh et al.

**摘要**:开发高特异性BCL2L12单克隆抗体,验证其在结直肠癌组织中的检测效果,结果表明BCL2L12过表达与肿瘤侵袭性及化疗耐药相关。

3. **文献名称**:*BCL2L12调控caspase-3活性促进乳腺癌细胞凋亡抵抗*

**作者**:Floros et al.

**摘要**:利用Western blot和免疫共沉淀技术,揭示BCL2L12通过抑制caspase-3活性介导乳腺癌细胞凋亡逃逸,其抗体在机制研究中起关键作用。

4. **文献名称**:*BCL2L12作为肺癌新型治疗靶点的功能研究*

**作者**:Kontos et al.

**摘要**:基于BCL2L12抗体的功能阻断实验,发现靶向BCL2L12可增强肺癌细胞对放疗的敏感性,为临床治疗提供新思路。

(注:以上内容为示例,实际文献需通过学术数据库检索确认。)

背景信息

The BCL2L12 (B-cell lymphoma 2-like 12) gene encodes a member of the BCL-2 protein family, which regulates apoptosis through interactions with pro- and anti-apoptotic molecules. Located on chromosome 12q24.31. BCL2L12 contains conserved BCL-2 homology (BH) domains and a unique C-terminal extension. Unlike classic BCL-2 members, BCL2L12 exhibits dual roles in apoptosis, acting as either a pro-survival or pro-apoptotic protein depending on cellular context, post-translational modifications, or splice variants. It interacts with p53. caspase-3. and other apoptotic regulators, influencing cell differentiation and tumorigenesis.

BCL2L12 is implicated in multiple cancers, including glioblastoma, colorectal carcinoma, and breast cancer. Overexpression correlates with poor prognosis in glioblastoma by inhibiting caspase-7 activation and promoting chemoresistance. Conversely, in some cancers, it may act as a tumor suppressor by sequestering anti-apoptotic proteins.

Antibodies targeting BCL2L12 are critical tools for studying its expression, localization, and interactions. They are used in Western blotting, immunohistochemistry (IHC), and immunocytochemistry (ICC) to assess protein levels in clinical samples or cell lines. Specific monoclonal and polyclonal antibodies help elucidate its role in apoptosis pathways, tumor progression, and therapeutic resistance. Commercial antibodies often target epitopes within its N-terminal or C-terminal regions, with validation in knockout models to confirm specificity. Research utilizing these antibodies has advanced understanding of BCL2L12’s dual functionality and its potential as a diagnostic biomarker or therapeutic target.

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