| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cancer/testis antigen 2.3; CT2.3; |
| Entrez GeneID | 85318; |
| WB Predicted band size | 12kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human BAGE3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于BAGE3抗体的3篇参考文献示例(内容基于模拟数据，建议通过学术数据库核实)：
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1. **文献名称**: *"BAGE3 as a Novel Tumor Antigen: Characterization of Specific Antibodies for Immunotherapy"*
**作者**: Li, X., et al.
**摘要**: 研究报道了BAGE3在多种实体瘤中的异常表达，并开发了针对BAGE3表位的单克隆抗体。实验表明，该抗体可通过抗体依赖性细胞毒性(ADCC)显著抑制小鼠模型中肿瘤的生长，提示其治疗潜力。
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2. **文献名称**: *"Immunohistochemical Detection of BAGE3 in Triple-Negative Breast Cancer: Correlation with Prognosis"*
**作者**: Martinez, R., et al.
**摘要**: 通过免疫组化分析，发现BAGE3在三阴性乳腺癌组织中高表达，且与不良预后相关。研究使用兔源多克隆抗体验证了BAGE3作为潜在生物标志物的价值，并探讨其与肿瘤侵袭性的分子机制。
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3. **文献名称**: *"Engineering a Humanized Anti-BAGE3 Antibody for Enhanced Cancer Targeting"*
**作者**: Kumar, S., et al.
**摘要**: 研究通过人源化改造小鼠抗BAGE3抗体，优化其亲和力与稳定性。体外实验显示，改造后的抗体能有效识别BAGE3阳性肿瘤细胞，并激活T细胞杀伤功能，为临床转化奠定基础。
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如需具体文献，建议通过 **PubMed** 或 **Web of Science** 检索关键词“BAGE3 antibody”、“BAGE3 immunotherapy”等获取最新研究。
The BAGE3 antibody targets the B melanoma antigen (BAGE) family member 3. a protein encoded by the BAGE3 gene located on chromosome 21. BAGE proteins belong to the cancer/testis antigen (CTA) family, characterized by restricted expression in normal tissues (primarily testis, placenta, and fetal ovary) but aberrant activation in various cancers. BAGE3 shares structural features with other CTAs, including a conserved PRAME-like domain, and is implicated in tumorigenesis through mechanisms involving immune evasion or epigenetic regulation.
BAGE3 antibodies are primarily used in research to study its role in cancer progression and as a biomarker. Overexpression of BAGE3 has been detected in malignancies such as melanoma, lung, breast, and ovarian cancers, correlating with poor prognosis. Its restricted normal tissue expression makes it a potential target for immunotherapy, including CAR-T cells or cancer vaccines. However, BAGE3's low immunogenicity and variable tumor expression pose challenges for therapeutic development. Current studies focus on validating its diagnostic utility and exploring combinatorial strategies to enhance immune targeting. Antibodies against BAGE3 also aid in elucidating its interaction with HLA molecules and T-cell responses, providing insights into tumor microenvironment dynamics.
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