| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ARSE; Arylsulfatase E; arylsulfatase E (chondrodysplasia punctata 1); ASE; CDPX |
| Entrez GeneID | 415; |
| WB Predicted band size | 66kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from Internal of human ARSE. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ARSE抗体的示例参考文献(注：以下内容为虚构示例，仅供参考，建议通过PubMed或Google Scholar检索真实文献)：
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1. **标题**：*Development of a Monoclonal Antibody for ARSE Enzyme Detection in Chondrodysplasia Punctata*
**作者**：Smith J, et al.
**摘要**：本研究开发了一种特异性识别芳香基硫酸酯酶E(ARSE)的单克隆抗体，用于分析X连锁点状软骨发育不良患者的酶表达水平。通过免疫印迹和免疫组化验证，该抗体可有效区分健康个体与ARSE基因突变患者的蛋白表达差异。
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2. **标题**：*ARSE Deficiency and Its Role in Skeletal Dysplasia: Insights from Antibody-Based Assays*
**作者**：Zhang L, et al.
**摘要**：通过抗ARSE抗体对患者成纤维细胞进行蛋白定位研究，发现ARSE酶在溶酶体功能中起关键作用。抗体检测显示，突变导致ARSE酶活性丧失，与骨骼发育异常密切相关。
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3. **标题**：*Diagnostic Utility of ARSE Autoantibodies in Metabolic Bone Disorders*
**作者**：Patel R, et al.
**摘要**：探讨ARSE自身抗体在代谢性骨病中的潜在诊断价值。研究发现，部分患者血清中存在抗ARSE抗体，可能干扰酶活性，提示其与疾病病理机制的相关性。
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4. **标题**：*ARSE Knockout Mouse Model Reveals Therapeutic Potential of Antibody-Mediated Enzyme Replacement*
**作者**：Kim S, et al.
**摘要**：利用ARSE抗体在基因敲除小鼠模型中评估酶替代疗法的效果。研究显示，抗体介导的靶向递送可部分恢复酶活性，改善骨骼表型。
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**建议**：如需真实文献，可检索关键词“ARSE antibody”“arylsulfatase E”或“chondrodysplasia punctata”结合“antibody”在学术数据库中查找。
**Background of ARSE Antibodies**
ARSE (Arylsulfatase E) antibodies target the ARSE enzyme, a sulfatase involved in the hydrolysis of sulfate esters from substrates like glycosaminoglycans. Encoded by the *ARSE* gene located on the X chromosome, this enzyme plays a critical role in skeletal development by regulating sulfate metabolism, essential for cartilage and bone formation. Mutations in *ARSE* are linked to X-linked recessive chondrodysplasia punctata 1 (CDPX1), a rare genetic disorder characterized by abnormal cartilage calcification, skeletal malformations, and stippled epiphyses observed in infancy.
ARSE antibodies are primarily used in research and diagnostics to study enzyme expression, localization, and dysfunction. In research, these antibodies help elucidate the molecular mechanisms underlying CDPX1 and assess the impact of *ARSE* mutations on sulfatase activity. Clinically, they aid in confirming CDPX1 diagnoses through immunohistochemistry or Western blotting, complementing genetic testing. Additionally, ARSE antibodies have potential applications in developing targeted therapies, such as enzyme replacement strategies or gene therapy for sulfatase deficiencies.
Despite their utility, challenges remain, including understanding ARSE's precise substrate specificity and its interactions in developmental pathways. Ongoing studies focus on refining antibody specificity and exploring ARSE's role beyond skeletal development, including potential implications in cellular signaling and metabolic regulation.
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