| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/100-1/500 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Arylsulfatase D; EC 3.1.6.-; ASD; |
| Entrez GeneID | 414; |
| WB Predicted band size | 65kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human ARSD. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于ARSD抗体的模拟参考文献示例(请注意这些文献信息为虚构，仅供示例参考)：
1. **"Characterization of a Novel Monoclonal Antibody Against Human ARSD for Cancer Biomarker Studies"**
- 作者：Smith J, et al.
- 摘要：开发并验证了一种靶向芳基硫酸酯酶D(ARSD)的单克隆抗体，证实其在结直肠癌组织中高表达，可能作为潜在诊断标志物。
2. **"ARSD Expression Profiling in Breast Cancer Using Immunohistochemistry"**
- 作者：Lee H, et al.
- 摘要：通过抗ARSD抗体进行免疫组化分析，发现ARSD在三阴性乳腺癌中显著上调，可能与肿瘤侵袭性相关。
3. **"Development of a Polyclonal Antibody for Detection of ARSD in Human Tissues"**
- 作者：Garcia R, et al.
- 摘要：报道了一种兔源多克隆抗体的制备方法，用于检测多种组织中的ARSD蛋白表达，验证了其在肾脏和肝脏中的分布差异。
4. **"ARSD Knockdown and Antibody-Based Functional Studies Reveal Its Role in Sulfatide Metabolism"**
- 作者：Chen L, et al.
- 摘要：结合RNA干扰和抗ARSD抗体功能抑制实验，揭示了ARSD在硫酸酯代谢通路中的关键作用及其与溶酶体疾病的关联。
**建议**：实际研究中请通过PubMed、Google Scholar等平台以“ARSD antibody”、“Arylsulfatase D”等关键词检索最新文献，并优先选择近5年高被引论文。
The ARSD (Arylsulfatase D) antibody is a research tool used to study the function and expression of the ARSD protein, a member of the sulfatase enzyme family. ARSD is encoded by the *ARSD* gene located on the X chromosome (Xp22.3) and is part of a larger family of arylsulfatases involved in hydrolyzing sulfate esters from various substrates, including glycosaminoglycans (GAGs). Unlike its more well-characterized homologs (e.g., ARSB or ARSE), ARSD's specific biological role remains less defined, though it is hypothesized to participate in lysosomal metabolism and cellular sulfate regulation.
ARSD antibodies are primarily utilized in experimental settings, such as Western blotting, immunohistochemistry, and immunofluorescence, to detect ARSD protein expression in tissues or cell lines. These antibodies aid in exploring ARSD's potential involvement in metabolic disorders, cancer, or other pathologies linked to sulfatase dysregulation. For instance, altered sulfatase activity has been associated with mucopolysaccharidoses and tumor progression. Researchers also employ ARSD antibodies to investigate gene expression patterns across developmental stages or under specific physiological conditions.
While ARSD is not directly linked to a major human disease like ARSB (deficiency of which causes Maroteaux-Lamy syndrome), its study contributes to understanding the broader sulfatase family's functional diversity and evolutionary conservation. Commercial ARSD antibodies are typically validated for specificity and sensitivity, though variability in isoforms or post-translational modifications may require careful experimental optimization.
×
