| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Arginase-2 mitochondrial; Arginase II; Non-hepatic arginase; Kidney-type arginase; |
| Entrez GeneID | 384; |
| WB Predicted band size | 38kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from C-terminal of human ARG2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是模拟生成的关于ARG2抗体的参考文献示例(请注意，这些文献信息为虚构示例，实际文献需通过学术数据库查询)：
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1. **文献名称**: "ARG2 Expression in Tumor-Associated Macrophages Promotes Immunosuppression and Predicts Poor Prognosis in Colorectal Cancer"
**作者**: Smith A, et al.
**摘要**: 该研究通过免疫组化技术使用特异性ARG2抗体，揭示了结直肠癌中肿瘤相关巨噬细胞高表达ARG2的现象，并证明其通过耗损局部精氨酸水平抑制T细胞活性，导致免疫逃逸。
2. **文献名称**: "Development of a Monoclonal Antibody for Specific Detection of Human Arginase 2 in Inflammatory Diseases"
**作者**: Zhang Y, et al.
**摘要**: 研究团队开发了一种高亲和力抗人ARG2单克隆抗体，验证了其在Western blot和流式细胞术中的特异性，为炎症性疾病中ARG2的定量检测提供了新工具。
3. **文献名称**: "ARG2 as a Therapeutic Target in Pulmonary Hypertension: Role of Antibody-Based Inhibition"
**作者**: Johnson R, et al.
**摘要**: 利用ARG2中和抗体阻断其酶活性，在肺动脉高压模型中显著改善血管重塑，表明靶向ARG2可能成为治疗代谢相关心血管疾病的新策略。
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**备注**：实际文献需通过PubMed、Web of Science等平台检索关键词(如“ARG2 antibody”“arginase 2 immune detection”)获取。建议结合研究领域(如肿瘤、免疫、代谢疾病)进一步筛选。
ARG2 (Arginase 2) is a mitochondrial enzyme that catalyzes the hydrolysis of L-arginine to L-ornithine and urea, playing a key role in the urea cycle and nitrogen metabolism. Unlike its isoform ARG1. which is primarily expressed in the liver, ARG2 is found in extrahepatic tissues, including kidney, brain, and immune cells, where it modulates L-arginine availability for downstream processes such as nitric oxide (NO) synthesis. By competing with nitric oxide synthase (NOS) for substrate, ARG2 influences NO-dependent signaling, impacting vascular function, immune responses, and cellular proliferation.
ARG2 antibodies are essential tools for studying the enzyme's expression, localization, and functional roles in physiological and pathological contexts. These antibodies enable detection of ARG2 in techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding research into diseases linked to arginine metabolism dysregulation. For instance, elevated ARG2 levels are associated with cardiovascular diseases, neurodegenerative disorders, and cancers, where it may promote immunosuppression by depleting arginine in the tumor microenvironment.
Commercial ARG2 antibodies are typically raised against peptide sequences unique to the ARG2 protein to ensure specificity. Validation includes testing in knockdown models or ARG2-deficient cells to confirm target selectivity. Researchers must consider cross-reactivity with ARG1 and species compatibility (human, mouse, rat) when selecting antibodies. Ongoing studies using ARG2 antibodies continue to clarify its therapeutic potential, particularly in targeting metabolic vulnerabilities in cancer or inflammatory diseases.
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