| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | AI; AI256583; Arg-1; ARGI1; arginase 1 |
| Entrez GeneID | 383; |
| WB Predicted band size | 35kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human ARG1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ARG1抗体的3篇参考文献示例(注：文献信息为模拟生成，仅供参考)：
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1. **文献名称**: "Arginase-1 is a key biomarker of hepatocellular carcinoma: development and validation of a monoclonal antibody-based immunohistochemical assay"
**作者**: Fujiwara N, et al.
**摘要**: 本研究开发了一种高特异性的ARG1单克隆抗体，并通过免疫组化验证其在肝细胞癌(HCC)中的表达。结果显示，ARG1在HCC组织中显著高表达，可作为区分HCC与其他肝脏肿瘤的可靠标志物。
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2. **文献名称**: "Differential expression of Arginase-1 in tumor-associated macrophages correlates with immunosuppressive microenvironment"
**作者**: Rodriguez PC, et al.
**摘要**: 通过ARG1抗体分析肿瘤微环境中M2型巨噬细胞的分布，发现ARG1阳性巨噬细胞与T细胞功能抑制及患者预后不良相关，提示ARG1可作为免疫治疗潜在靶点。
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3. **文献名称**: "Arginase-1 antibody-based flow cytometry enables rapid M1/M2 macrophage polarization assessment"
**作者**: Murray PJ, et al.
**摘要**: 利用ARG1抗体优化流式细胞术方案，实现了M2型巨噬细胞的高效分型。该方法在炎症性疾病模型中验证，证实ARG1表达与促修复型巨噬细胞功能密切相关。
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如需实际文献，建议通过PubMed或Google Scholar检索关键词“Arginase-1 antibody”+具体应用领域(如cancer, immunology)。
ARG1 (Arginase 1) is a manganese-containing enzyme that catalyzes the hydrolysis of arginine to ornithine and urea, playing a critical role in the urea cycle and nitrogen metabolism. Primarily expressed in the liver, ARG1 is also found in immune cells, such as myeloid-derived suppressor cells (MDSCs) and alternatively activated macrophages (M2), where it modulates immune responses by depleting arginine, an essential amino acid for T-cell function. Dysregulation of ARG1 is linked to metabolic disorders, liver diseases, and cancer immune evasion.
ARG1 antibodies are essential tools for detecting and quantifying ARG1 expression in research and diagnostics. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry to study tissue-specific expression, cellular localization, and functional roles of ARG1 in both physiological and pathological contexts. In cancer biology, these antibodies help investigate ARG1's contribution to immunosuppressive microenvironments, while in hepatology, they aid in diagnosing urea cycle disorders or liver damage. Commercial ARG1 antibodies are typically raised against specific epitopes of human or murine ARG1. with validation in relevant models. Researchers must select antibodies validated for their intended applications, as cross-reactivity or batch variability can affect results. Overall, ARG1 antibodies are pivotal in advancing studies of metabolism, immunology, and disease mechanisms.
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