Rabbit Polyclonal ARFIP1 Antibody

ARFIP1 (ADP-ribosylation factor-interacting protein 1) is a regulatory protein involved in intracellular trafficking and cytoskeletal dynamics by interacting with ARF GTPases, which are critical for vesicle formation, membrane trafficking, and cell signaling. ARFIP1 modulates ARF activity by influencing GTP/GDP exchange or effector binding, thereby regulating processes like endocytosis, Golgi transport, and actin remodeling. Antibodies targeting ARFIP1 are essential tools for studying its expression, localization, and function in cellular pathways. These antibodies, often developed in hosts like rabbits or mice, enable techniques such as Western blotting, immunofluorescence, and co-immunoprecipitation to assess protein levels, subcellular distribution, and interaction partners. Research using ARFIP1 antibodies has linked the protein to neurological disorders, cancer progression, and metabolic dysregulation, highlighting its role in maintaining cellular homeostasis. Validation of antibody specificity (e.g., via knockout controls) ensures reliability in distinguishing ARFIP1 from related isoforms. Such studies contribute to understanding disease mechanisms and identifying potential therapeutic targets tied to ARF-mediated pathways.