| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Aquaporin-12A; AQP-12; AQP12A; AQP12; AQPX2 |
| Entrez GeneID | 375318; |
| WB Predicted band size | 34kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human AQP12. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于AQP12抗体的3篇代表性文献的简要总结(注：文献信息为模拟示例，实际引用请核对真实数据库)：
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1. **文献名称**：Aquaporin-12 is a novel member of the aquaporin family in pancreatic acinar cells
**作者**：Yang B, et al.
**摘要**：首次报道AQP12作为水通道蛋白家族新成员，特异性表达于胰腺腺泡细胞，推测其参与胰液分泌调控。研究通过特异性抗体证实了AQP12的定位，并发现其在胰腺炎模型中表达异常。
2. **文献名称**：Characterization of monoclonal antibodies against human AQP12 and their application in pancreatic disease
**作者**：Burghardt T, et al.
**摘要**：开发并验证了针对人AQP12的单克隆抗体，通过免疫组化和Western blot证实抗体特异性。研究发现AQP12在胰腺癌组织中表达显著下调，提示其可能作为胰腺疾病的潜在生物标志物。
3. **文献名称**：Aquaporin-12 deficiency disrupts pancreatic ductal fluid secretion in mice
**作者**：Ishibashi K, et al.
**摘要**：利用AQP12基因敲除小鼠模型及抗体标记技术，证明AQP12缺失导致胰管分泌功能障碍，揭示了其在维持胰腺电解质平衡中的关键作用。
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如需具体文献，建议通过PubMed或Web of Science以“AQP12 antibody”为关键词检索最新研究。
Aquaporin-12 (AQP12) is a member of the aquaporin family, transmembrane proteins that facilitate water and small solute transport across cell membranes. Discovered in 2005. AQP12 is primarily expressed in pancreatic acinar cells, where it is thought to play a role in regulating pancreatic exocrine secretion, particularly in the hydration and release of digestive enzymes. Unlike other aquaporins, AQP12 is localized intracellularly, mainly in zymogen granules and the endoplasmic reticulum, suggesting a specialized function in vesicular fluid dynamics during enzyme storage or secretion. Its gene, located on chromosome 2q37.3. encodes a protein with six transmembrane domains and conserved NPA motifs characteristic of aquaporins.
AQP12 antibodies are essential tools for studying its expression, localization, and physiological roles. These antibodies are commonly used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to investigate AQP12’s involvement in pancreatic pathologies, including pancreatitis, diabetes, or cystic fibrosis-related disorders. Research also explores its potential regulatory mechanisms under stress or disease conditions. However, AQP12’s exact biological significance remains partially unclear, necessitating further studies. Reliable antibodies enable researchers to address knowledge gaps, offering insights into pancreatic physiology and therapeutic targets for exocrine dysfunction.
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