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Rabbit Polyclonal APOA5 Antibody

  • 中文名: APOA5抗体
  • 别    名: Apolipoprotein A-V; Apo-AV; ApoA-V; Apolipoprotein A5; Regeneration-associated protein 3
货号: IPDX42280
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesApolipoprotein A-V; Apo-AV; ApoA-V; Apolipoprotein A5; Regeneration-associated protein 3
Entrez GeneID116519;
WB Predicted band size41kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthesized peptide derived from internal of human APOA5.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于APOA5抗体的3篇示例文献(内容为模拟概括,仅供参考,实际文献需通过学术数据库验证):

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1. **文献名称**: *"Monoclonal antibody targeting APOA5 modulates triglyceride metabolism in hyperlipidemic mice"*

**作者**: Smith J, et al.

**摘要**: 研究开发了一种特异性识别APOA5的单克隆抗体,通过小鼠模型证明其能结合循环APOA5蛋白,降低血浆甘油三酯水平,提示其在治疗高甘油三酯血症中的潜力。

2. **文献名称**: *"APOA5 gene variants and antibody-based detection of APOA5 isoforms in human plasma"*

**作者**: Chen L, et al.

**摘要**: 分析了APOA5基因突变与蛋白表达的关系,利用多克隆抗体通过ELISA技术检测人类血浆中APOA5的不同异构体,发现特定突变导致APOA5功能缺失与心血管疾病风险相关。

3. **文献名称**: *"Autoantibodies against APOA5 as a novel biomarker for metabolic syndrome"*

**作者**: Tanaka K, et al.

**摘要**: 首次报道了代谢综合征患者体内存在抗APOA5自身抗体,并通过队列研究发现此类抗体与胰岛素抵抗、血脂异常显著相关,提示其作为临床生物标志物的可能性。

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**注意**:以上文献信息为示例性概括,并非真实存在的论文。建议通过PubMed、Web of Science等平台检索关键词(如APOA5 antibody、APOA5 autoantibodies)获取准确文献。

背景信息

Apolipoprotein A-V (APOA5), a key regulator of triglyceride metabolism, is a plasma protein primarily synthesized in the liver. It enhances lipoprotein lipase (LPL)-mediated hydrolysis of triglyceride-rich lipoproteins (TRLs) and facilitates hepatic uptake of their remnants, thereby critically influencing plasma triglyceride levels. Genetic variations in the APOA5 gene are strongly associated with hypertriglyceridemia, a risk factor for cardiovascular diseases and pancreatitis.

APOA5 antibodies are essential tools for studying its structure, function, and pathological mechanisms. These antibodies enable detection and quantification of APOA5 in biological samples via techniques like ELISA, Western blotting, and immunohistochemistry. Researchers use them to explore APOA5's role in lipid metabolism disorders, including metabolic syndrome, diabetes, and atherosclerosis. Additionally, APOA5 antibodies aid in elucidating how specific gene mutations or polymorphisms (e.g., -1131T>C, S19W) impair protein expression or function, contributing to dyslipidemia.

Therapeutic applications are also emerging. Neutralizing antibodies or recombinant APOA5 mimetics are being investigated to modulate triglyceride levels, offering potential treatments for severe hypertriglyceridemia. However, challenges remain, such as low plasma APOA5 concentrations and its rapid turnover, complicating clinical translation. Overall, APOA5 antibodies serve as both research reagents and potential diagnostic/therapeutic agents, bridging mechanistic insights and clinical interventions in lipid-related diseases.

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