Rabbit Polyclonal KANK2 Antibody

The KANK2 antibody is a tool used to detect the KANK2 (KN motif and ankyrin repeat domain-containing 2) protein, which plays roles in cytoskeletal organization, cell adhesion, and migration. KANK2 belongs to the KANK family, characterized by an N-terminal KN motif and C-terminal ankyrin repeats. These domains mediate interactions with proteins like β-catenin and integrins, influencing signaling pathways linked to cell polarity and motility. Dysregulation of KANK2 has been implicated in cancers, including renal and breast carcinomas, where it may act as a tumor suppressor by inhibiting proliferation or metastasis. Research using KANK2 antibodies has helped elucidate its localization at cell-cell junctions and its role in maintaining tissue architecture. Commercially available antibodies (polyclonal/monoclonal) are validated for techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Recent studies also explore KANK2’s involvement in neurological disorders and developmental defects, highlighting its broader functional significance. Reliable KANK2 antibodies are critical for advancing mechanistic studies and potential clinical applications, including biomarker discovery or targeted therapies.