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Rabbit Polyclonal KANK2 Antibody

  • 中文名： KANK2抗体
  • 别    名： Ankyrin repeat domain-containing protein 25; SRC-1-interacting protein; SRC1-interacting protein; Matrix-remodeling-associated protein 3;
货号: IPDX42277
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 1/100-1/500 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesAnkyrin repeat domain-containing protein 25; SRC-1-interacting protein; SRC1-interacting protein; Matrix-remodeling-associated protein 3;
Entrez GeneID25959;
WB Predicted band size92kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthesized peptide derived from internal of human KANK2.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于KANK2抗体的3篇虚构参考文献示例(仅供参考，实际文献需通过数据库检索获取)：

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1. **Title**: *KANK2 regulates cell migration through interaction with β1-integrin in breast cancer*

**Authors**: Chen L, et al.

**Summary**: 本研究利用KANK2特异性抗体，通过免疫共沉淀和免疫荧光技术，揭示了KANK2通过结合β1-整合素调控乳腺癌细胞迁移的分子机制，为靶向细胞骨架的癌症治疗提供新思路。

2. **Title**: *KANK2 antibody-based profiling identifies reduced expression in diabetic nephropathy*

**Authors**: Gupta S, et al.

**Summary**: 通过Western blot和免疫组化分析，发现糖尿病肾病患者肾组织中KANK2蛋白表达显著下调，提示其可能参与维持足细胞结构和功能，为肾脏疾病生物标志物研究提供依据。

3. **Title**: *Structural insights into KANK2-PIPKIγ complex using epitope-specific antibodies*

**Authors**: Müller R, et al.

**Summary**: 本研究开发了靶向KANK2 C端结构域的高特异性抗体，解析了KANK2与磷脂酶PIPKIγ的相互作用，阐明其在细胞极性建立中的关键作用。

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如需真实文献，建议通过PubMed或Google Scholar检索关键词“KANK2 antibody”或“KANK2 function”。

背景信息

The KANK2 antibody is a tool used to detect the KANK2 (KN motif and ankyrin repeat domain-containing 2) protein, which plays roles in cytoskeletal organization, cell adhesion, and migration. KANK2 belongs to the KANK family, characterized by an N-terminal KN motif and C-terminal ankyrin repeats. These domains mediate interactions with proteins like β-catenin and integrins, influencing signaling pathways linked to cell polarity and motility. Dysregulation of KANK2 has been implicated in cancers, including renal and breast carcinomas, where it may act as a tumor suppressor by inhibiting proliferation or metastasis. Research using KANK2 antibodies has helped elucidate its localization at cell-cell junctions and its role in maintaining tissue architecture. Commercially available antibodies (polyclonal/monoclonal) are validated for techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Recent studies also explore KANK2’s involvement in neurological disorders and developmental defects, highlighting its broader functional significance. Reliable KANK2 antibodies are critical for advancing mechanistic studies and potential clinical applications, including biomarker discovery or targeted therapies.

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