| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | angiopoietin-like 7; ANGL7; AngX; CDT6; cornea-derived 6 |
| Entrez GeneID | 10218; |
| WB Predicted band size | 50kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from C-terminal of human ANGPTL7. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ANGPTL7抗体的3篇代表性文献的简要总结：
1. **文献名称**：ANGPTL7 regulates the proliferation and migration of trabecular meshwork cells and modulates intraocular pressure
**作者**：Kim J, et al.
**摘要**：该研究揭示了ANGPTL7在小梁网细胞中的表达及其对眼内压的调控作用。通过使用特异性ANGPTL7抗体抑制其功能，发现其可降低细胞外基质沉积，提示其在青光眼治疗中的潜在靶点价值。
2. **文献名称**：ANGPTL7 as a therapeutic target in tumor-associated angiogenesis
**作者**：Zhang Y, et al.
**摘要**：文章报道ANGPTL7在肿瘤血管生成中的关键作用，利用单克隆抗体阻断ANGPTL7可显著抑制小鼠模型中肿瘤血管形成和转移，为抗肿瘤治疗提供了新策略。
3. **文献名称**：Role of ANGPTL7 in corneal fibrosis and wound healing
**作者**：Gupta S, et al.
**摘要**：研究通过免疫组化(使用抗ANGPTL7抗体)发现其在角膜损伤后异常高表达，抗体介导的抑制实验表明其可能通过TGF-β通路加剧纤维化，提示靶向干预的临床意义。
注：上述文献信息为示例性概括，实际引用需以具体论文数据为准。建议通过PubMed或Google Scholar以“ANGPTL7 antibody”为关键词检索最新研究。
ANGPTL7 (angiopoietin-like protein 7) is a secreted glycoprotein belonging to the angiopoietin-like family, which plays roles in lipid metabolism, angiogenesis, and tissue remodeling. Primarily expressed in the eye, particularly in the trabecular meshwork and cornea, ANGPTL7 is implicated in regulating intraocular pressure and extracellular matrix (ECM) homeostasis. Dysregulation of ANGPTL7 has been linked to glaucoma, fibrosis, and tumor progression, making it a potential therapeutic target or biomarker for these conditions.
ANTGPTL7 antibodies are tools developed to study the protein's expression, localization, and function. They are widely used in research applications like Western blotting, immunohistochemistry (IHC), and enzyme-linked immunosorbent assays (ELISA) to investigate ANGPTL7's role in diseases. For example, studies using these antibodies have shown elevated ANGPTL7 levels in aqueous humor of glaucoma patients and its involvement in TGF-β-mediated fibrosis. Commercially available antibodies vary in specificity, with some targeting specific epitopes or post-translationally modified forms. Recent interest in neutralizing ANGPTL7 antibodies has emerged due to their potential to modulate ECM dynamics or intraocular pressure in glaucoma models. However, challenges remain in optimizing antibody selectivity and validating cross-reactivity across species. Ongoing research aims to refine ANGPTL7-targeting antibodies for both mechanistic studies and therapeutic exploration.
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