Rabbit Polyclonal AKR1CL2 Antibody

The AKR1CL2 antibody targets the aldo-keto reductase family 1 member C-like 2 (AKR1CL2), a protein belonging to the AKR superfamily involved in metabolic pathways, steroid hormone regulation, and detoxification. AKR1CL2. also termed "uncharacterized AKR1C member," shares structural homology with other AKR1C enzymes but lacks well-defined catalytic activity. Its gene is located on chromosome 10p15.1 and is expressed in various tissues, including the liver, prostate, and adrenal glands. While its precise biological role remains unclear, studies suggest potential involvement in steroid metabolism, particularly in modulating androgen or estrogen signaling pathways. Research on AKR1CL2 has been limited compared to other AKR1C isoforms (e.g., AKR1C1-4), partly due to ambiguous functional annotations and overlapping substrate specificities within the family. Antibodies against AKR1CL2 are primarily used to investigate its expression patterns, subcellular localization, and potential associations with diseases such as hormone-related cancers. However, specificity challenges persist due to high sequence similarity among AKR1C members. Recent interest in AKR1CL2 stems from its differential expression in cancer proteomic studies, though functional validation remains ongoing. Researchers often employ these antibodies in techniques like Western blotting, immunohistochemistry, or immunofluorescence, typically paired with genetic knockdowns to confirm target specificity.