Rabbit Polyclonal ACOT1 Antibody

The acyl-CoA thioesterase 1 (ACOT1) antibody is a tool used to study the ACOT1 enzyme, which belongs to the acyl-CoA thioesterase family. ACOT1 catalyzes the hydrolysis of acyl-CoA thioesters into free fatty acids and coenzyme A, playing a critical role in lipid metabolism, energy homeostasis, and cellular signaling. It is primarily localized in mitochondria and peroxisomes, with high expression in metabolic tissues like the liver, heart, and skeletal muscle. ACOT1 regulates fatty acid oxidation and synthesis by controlling acyl-CoA availability, impacting processes such as β-oxidation and lipid droplet dynamics. Dysregulation of ACOT1 has been linked to metabolic disorders, including obesity, diabetes, and non-alcoholic fatty liver disease. Research also suggests its involvement in cancer progression and neuroinflammation. The ACOT1 antibody enables detection and quantification of ACOT1 protein levels in experimental models, aiding investigations into its physiological and pathological roles. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study tissue-specific expression, subcellular localization, and regulatory mechanisms. Developing specific and reliable ACOT1 antibodies remains essential for advancing studies on lipid metabolism and associated diseases.