| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/100-1/500 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Abhydrolase domain-containing protein 6; EC 3.-.-.-; ABHD6; |
| Entrez GeneID | 57406; |
| WB Predicted band size | 38kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from internal of human ABHD6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ABHD6抗体的3篇参考文献示例(注：内容基于公开文献概括，具体文献可能存在调整)：
1. **文献名称**：*ABHD6 regulates neuroinflammatory responses in microglia through enzymatic and non-enzymatic mechanisms*
**作者**：M. Thomas et al.
**摘要**：研究利用特异性ABHD6抗体，发现ABHD6通过水解内源性大麻素2-AG及调控炎症信号通路，影响小胶质细胞的神经炎症反应，可能成为神经退行性疾病的潜在靶点。
2. **文献名称**：*Selective antibody-based inhibition of ABHD6 in aggressive cancers*
**作者**：S. Patel et al.
**摘要**：通过开发高选择性ABHD6单克隆抗体，研究证明抑制ABHD6的酶活性可阻断癌细胞脂代谢重编程，显著抑制肿瘤生长，为癌症治疗提供新策略。
3. **文献名称**：*ABHD6 antibody-based detection reveals tissue-specific expression in metabolic organs*
**作者**：K. Lee & J. Zhang
**摘要**：利用免疫组化及Western blot分析，发现ABHD6在肝脏和脂肪组织中高表达，抗体特异性验证表明其与肥胖相关代谢调控密切相关。
4. **文献名称**：*Development of a rabbit monoclonal antibody panel for ABHD6 functional studies*
**作者**：R. Gupta et al.
**摘要**：研究报道了新型兔源ABHD6单克隆抗体的开发，验证其在不同模型中的应用效果，为ABHD6的分子机制研究提供了可靠工具。
(注：以上为模拟内容，实际文献需通过学术数据库检索确认。)
ABHD6 (α/β-hydrolase domain-containing protein 6) is a serine hydrolase enzyme belonging to the endocannabinoid system, primarily known for its role in hydrolyzing the major endogenous cannabinoid 2-arachidonoylglycerol (2-AG). Discovered in the early 2000s, ABHD6 regulates 2-AG signaling by breaking it down into arachidonic acid and glycerol, modulating synaptic transmission, neuroinflammation, and energy metabolism. Its expression is widespread, with high levels in the brain, liver, and adipose tissues, linking it to neurological disorders (e.g., epilepsy, neuropathic pain) and metabolic diseases (e.g., obesity, diabetes).
ABHD6 antibodies are essential tools for studying the enzyme's localization, expression, and function. They enable detection and quantification of ABHD6 in tissues or cell lysates via techniques like Western blotting, immunohistochemistry, and flow cytometry. Researchers also use these antibodies to explore ABHD6's interactions with inhibitors or substrates, aiding drug development for conditions where ABHD6 dysregulation is implicated. Recent studies highlight ABHD6 as a therapeutic target, with selective inhibitors showing potential in preclinical models of neurodegeneration and metabolic syndrome. However, antibody specificity remains a challenge due to homology with other hydrolases, necessitating rigorous validation. Advances in antibody engineering continue to improve their reliability, supporting ongoing research into ABHD6's multifaceted roles in health and disease.
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