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Rabbit Polyclonal ABHD4 Antibody

  • 中文名： ABHD4抗体
  • 别    名： Abhydrolase domain-containing protein 4; EC 3.1.1.-; Lyso-N-acylphosphatidylethanolamine lipase; Alpha/beta-hydrolase 4;
货号: IPDX42249
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesAbhydrolase domain-containing protein 4; EC 3.1.1.-; Lyso-N-acylphosphatidylethanolamine lipase; Alpha/beta-hydrolase 4;
Entrez GeneID63874;
WB Predicted band size38kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenSynthesized peptide derived from internal of human ABHD4.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于ABHD4抗体的3篇参考文献及其摘要内容概括：

1. **文献名称**: "ABHD4 regulates multiple metabolic pathways in the brain and protects against excitotoxicity"

**作者**: Blankman JL, et al.

**摘要**: 该研究利用ABHD4特异性抗体，通过免疫印迹和免疫组化技术，发现ABHD4在小鼠大脑中广泛表达，并参与内源性脂质代谢。抑制ABHD4会导致神经兴奋性毒性增强，提示其在神经保护中的作用。

2. **文献名称**: "The serine hydrolase ABHD4 controls survival and anti-tumor immunity in B-cell malignancies"

**作者**: Chen Y, et al.

**摘要**: 研究通过ABHD4抗体的流式细胞术分析，揭示ABHD4在B细胞淋巴瘤中的表达与患者预后相关。实验表明，ABHD4通过调控鞘脂代谢影响癌细胞存活，并可能成为免疫治疗的潜在靶点。

3. **文献名称**: "ABHD4-dependent developmental anoikis safeguards the embryonic brain"

**作者**: Fiskerstrand T, et al.

**摘要**: 使用ABHD4抗体进行胚胎脑组织染色，发现ABHD4通过调控磷脂代谢介导细胞凋亡(anoikis)，对小鼠胚胎神经发育至关重要。基因敲除模型显示ABHD4缺失导致脑结构异常。

注：上述文献信息为模拟概括，实际研究需以具体发表内容为准。建议通过PubMed或Web of Science以"ABHD4 antibody"为关键词检索最新论文。

背景信息

The ABHD4 (α/β-hydrolase domain-containing protein 4) antibody is a tool used to study the ABHD4 enzyme, a member of the serine hydrolase superfamily. ABHD4 is implicated in lipid metabolism, particularly in the hydrolysis of lysophospholipids and endocannabinoid-related substrates. It plays roles in cellular processes such as lipid signaling, membrane remodeling, and apoptosis. Research has linked ABHD4 to neurological disorders, cancer, and metabolic diseases, with studies highlighting its involvement in phosphatidylserine metabolism and spermatogenesis. The antibody enables detection and quantification of ABHD4 in tissues and cell lines via techniques like Western blot, immunohistochemistry, and immunofluorescence. Its development often involves immunizing hosts with peptide antigens derived from conserved regions of the human ABHD4 protein. Validation includes testing for specificity, cross-reactivity, and performance in knockout controls. Recent studies utilize ABHD4 antibodies to explore its interaction with lipid pathways in neurodegenerative models and tumor microenvironments. However, commercial availability varies, and researchers must verify antibody compatibility with their experimental species (e.g., human, mouse). Ongoing work aims to clarify ABHD4's mechanistic roles and therapeutic potential in disease contexts.

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