Rabbit Polyclonal ABHD4 Antibody

The ABHD4 (α/β-hydrolase domain-containing protein 4) antibody is a tool used to study the ABHD4 enzyme, a member of the serine hydrolase superfamily. ABHD4 is implicated in lipid metabolism, particularly in the hydrolysis of lysophospholipids and endocannabinoid-related substrates. It plays roles in cellular processes such as lipid signaling, membrane remodeling, and apoptosis. Research has linked ABHD4 to neurological disorders, cancer, and metabolic diseases, with studies highlighting its involvement in phosphatidylserine metabolism and spermatogenesis. The antibody enables detection and quantification of ABHD4 in tissues and cell lines via techniques like Western blot, immunohistochemistry, and immunofluorescence. Its development often involves immunizing hosts with peptide antigens derived from conserved regions of the human ABHD4 protein. Validation includes testing for specificity, cross-reactivity, and performance in knockout controls. Recent studies utilize ABHD4 antibodies to explore its interaction with lipid pathways in neurodegenerative models and tumor microenvironments. However, commercial availability varies, and researchers must verify antibody compatibility with their experimental species (e.g., human, mouse). Ongoing work aims to clarify ABHD4's mechanistic roles and therapeutic potential in disease contexts.