| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ABHDB; abhydrolase domain containing 11; EC 3.-.-.-; PP1226; WBSCR21 |
| Entrez GeneID | 83451; |
| WB Predicted band size | 32kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human ABHD11. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ABHD11抗体的3篇参考文献概览(注：文献为虚拟示例，仅供格式参考)：
1. **"ABHD11 regulates amyloid-beta metabolism in Alzheimer’s disease models"**
- 作者：Smith J, et al.
- 摘要：研究通过开发特异性ABHD11抗体，发现其在阿尔茨海默病模型中调控β-淀粉样蛋白代谢，抗体用于检测脑组织中ABHD11的蛋白表达及亚细胞定位。
2. **"Characterization of a novel monoclonal antibody against ABHD11 for immunohistochemical applications"**
- 作者：Li X, et al.
- 摘要：报道了一种新型ABHD11单克隆抗体的开发与验证，该抗体在多种组织样本中表现出高特异性和灵敏度，适用于免疫组化和Western blot分析。
3. **"ABHD11 interacts with mitochondrial proteins: Insights from co-immunoprecipitation studies"**
- 作者：Garcia R, et al.
- 摘要：利用ABHD11抗体进行免疫共沉淀实验，发现其与线粒体功能相关蛋白的相互作用，提示ABHD11可能在细胞能量代谢中发挥作用。
**说明**：以上文献为示例，实际研究中建议通过PubMed或Web of Science检索真实文献。若需具体文献协助，可提供更详细的研究背景。
The ABHD11 (abhydrolase domain-containing protein 11) antibody is a tool used to detect and study the ABHD11 protein, a member of the α/β-hydrolase superfamily. This family is characterized by a conserved catalytic triad (serine, aspartate, histidine) and diverse roles in lipid metabolism, signaling, and other cellular processes. ABHD11. however, remains poorly characterized compared to other family members. It is a 28 kDa protein encoded by the ABHD11 gene located on human chromosome 7p22.1. Early studies suggest its potential involvement in mitochondrial function and interactions with proteins linked to neurodegenerative diseases, such as PARK7/DJ-1. which is associated with early-onset Parkinson’s disease.
ABHD11 antibodies are primarily utilized in research to investigate the protein’s expression, localization, and function via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Commercial antibodies are typically raised in rabbits or mice using peptide antigens derived from human ABHD11 sequences. Validation data often emphasize specificity through knockout controls or siRNA knockdown. Recent interest in ABHD11 stems from its possible roles in cancer progression and metabolic disorders, though mechanistic insights remain limited. Challenges include verifying antibody cross-reactivity across species and distinguishing isoforms. Overall, ABHD11 antibodies serve as critical reagents for unraveling the protein’s biological significance and its potential as a therapeutic or diagnostic target.
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