Rabbit Polyclonal RPL3L Antibody

The RPL3L (Ribosomal Protein L3-like) antibody is a tool used to detect the RPL3L protein, a paralog of the ribosomal protein RPL3. Both RPL3 and RPL3L are components of the 60S ribosomal subunit, playing roles in ribosome assembly and translation. However, RPL3L exhibits tissue-specific expression, predominantly in striated muscles (cardiac and skeletal) and certain brain regions, unlike the ubiquitously expressed RPL3. This divergence suggests specialized roles in regulating translation within metabolically active tissues. RPL3L is encoded by a gene on chromosome 16 in humans and shares high sequence homology with RPL3. complicating antibody specificity. High-quality RPL3L antibodies are validated to distinguish between the two paralogs, often through knockout controls or tissue-specific expression patterns. Research using RPL3L antibodies has linked the protein to muscle physiology, cardiac function, and neurological processes. Dysregulation of RPL3L has been implicated in cardiomyopathies, muscular disorders, and neurodegenerative diseases, highlighting its potential as a biomarker or therapeutic target. Studies also explore its role in adaptive ribosome specialization, where tissue-specific ribosomal proteins fine-tune translation efficiency for specialized cellular needs. The antibody is widely utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to map expression patterns and investigate molecular mechanisms in health and disease.