| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 39S ribosomal protein L13; mitochondrial; L13mt; MRP-L13; MRPL13 |
| Entrez GeneID | 28998; |
| WB Predicted band size | 24kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from C-terminal of human MRPL13. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MRPL13抗体的3篇参考文献示例(注：内容为模拟生成，实际文献需通过学术数据库检索确认)：
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1. **文献名称**: *Mitochondrial ribosomal protein L13 is critical for ribosome stability and cell apoptosis*
**作者**: Zhang Y, et al.
**摘要**: 本研究利用MRPL13抗体通过Western blot和免疫荧光技术，验证了MRPL13在线粒体核糖体组装中的关键作用。实验表明，MRPL13缺失会导致线粒体翻译功能障碍，并激活caspase依赖性细胞凋亡通路。
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2. **文献名称**: *MRPL13 as a potential biomarker in breast cancer progression*
**作者**: Lee S, et al.
**摘要**: 通过免疫组化(使用MRPL13抗体)分析乳腺癌组织样本，发现MRPL13表达水平与肿瘤代谢活跃性呈正相关，提示其可能作为线粒体功能异常的分子标志物，并影响化疗耐药性。
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3. **文献名称**: *A novel mutation in MRPL13 disrupts mitochondrial translation in neurodegenerative disorders*
**作者**: Gupta R, et al.
**摘要**: 本研究在阿尔茨海默病模型中，通过CRISPR敲除结合MRPL13抗体检测，证实MRPL13突变会干扰线粒体核糖体复合物形成，导致神经元ATP合成减少和氧化应激加剧。
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4. **文献名称**: *Targeting mitochondrial ribosomes: MRPL13 antibody-based screening for antiviral drug discovery*
**作者**: Chen H, et al.
**摘要**: 利用MRPL13抗体进行高通量筛选，发现某些小分子化合物可通过结合MRPL13抑制病毒依赖的线粒体翻译过程，为抗RNA病毒药物开发提供新靶点。
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如需具体文献，建议通过PubMed或Google Scholar检索关键词“MRPL13 antibody”或“mitochondrial ribosomal protein L13”获取最新研究。
The MRPL13 antibody is a research tool designed to detect and study mitochondrial ribosomal protein L13 (MRPL13), a key component of the mitochondrial ribosome's large subunit (39S). Encoded by nuclear DNA, MRPL13 plays a critical role in mitochondrial protein synthesis, which is essential for oxidative phosphorylation and cellular energy production. Mitochondrial ribosomes differ from their cytoplasmic counterparts, as they translate mitochondrial DNA-encoded mRNAs required for electron transport chain complexes. Dysregulation of mitochondrial ribosomal proteins, including MRPL13. has been linked to mitochondrial disorders, cancer progression, and neurodegenerative diseases.
The MRPL13 antibody is typically produced in hosts like rabbits or mice using immunogenic peptides or recombinant proteins. It enables researchers to investigate MRPL13 expression, localization, and function through techniques such as Western blotting, immunofluorescence, or immunohistochemistry. Validated antibodies are often tested for specificity using knockout cell lines or siRNA knockdown to confirm target recognition.
Studies utilizing MRPL13 antibodies contribute to understanding mitochondrial dysfunction in pathologies like metabolic syndromes, aging-related diseases, or chemotherapy resistance. Additionally, they aid in exploring tissue-specific expression patterns and post-translational modifications of MRPL13. providing insights into its regulatory roles in cellular homeostasis and disease mechanisms.
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