| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | mitochondrial ribosomal protein S16; MRP-S16; RPMS16; RT16; S16mt |
| Entrez GeneID | 51021; |
| WB Predicted band size | 15kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human MRPS16. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MRPS16抗体的3篇参考文献示例(文献信息为虚构示例，仅供参考格式)：
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1. **文献名称**: *MRPS16 regulates mitochondrial translation and apoptosis in cancer cells*
**作者**: Zhang L, et al.
**摘要**: 本研究通过Western blot和免疫荧光技术，利用MRPS16抗体揭示其在肝癌细胞线粒体翻译中的关键作用。结果显示，MRPS16下调导致线粒体蛋白合成障碍，并激活caspase依赖的凋亡通路。
2. **文献名称**: *A novel MRPS16 mutation linked to mitochondrial encephalopathy*
**作者**: Thompson R, et al.
**摘要**: 通过免疫组化结合MRPS16特异性抗体，研究者发现患者成纤维细胞中MRPS16蛋白表达显著降低，导致线粒体呼吸链复合物缺陷，证实MRPS16突变与儿童神经退行性疾病相关。
3. **文献名称**: *MRPS16 antibody-based profiling in aging and oxidative stress*
**作者**: Kim S, et al.
**摘要**: 利用MRPS16抗体分析老年小鼠组织样本，发现氧化应激条件下MRPS16蛋白水平下降，提示其可能通过调控线粒体ROS平衡参与衰老过程。
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**注意**：以上文献为模拟示例，实际研究中建议通过PubMed、Google Scholar等平台检索真实文献(关键词如“MRPS16 antibody”、“MRPS16 mitochondrial function”)。
The MRPS16 antibody is a research tool targeting mitochondrial ribosomal protein S16. a component of the small subunit (28S) of the mitochondrial ribosome (mitoribosome). MRPS16 plays a critical role in mitochondrial protein synthesis by facilitating the assembly and stability of the mitoribosome, which translates mitochondrial DNA-encoded genes. These genes produce subunits of the electron transport chain (ETC) complexes essential for oxidative phosphorylation (OXPHOS) and cellular energy production. Dysregulation of MRPS16 has been linked to mitochondrial dysfunction, contributing to metabolic disorders, neurodegenerative diseases, and cancer progression.
As a reagent, the MRPS16 antibody is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study mitochondrial protein expression, localization, and ribosome biogenesis. It helps investigate mitochondrial disorders caused by mutations in nuclear-encoded mitoribosomal proteins, such as combined oxidative phosphorylation deficiency syndromes. Additionally, it serves as a biomarker in studies exploring mitochondrial adaptation in cancer cells or metabolic stress responses.
Commercial MRPS16 antibodies are typically raised in rabbits or mice using synthetic peptides or recombinant proteins. Researchers must validate specificity via knockout controls due to potential cross-reactivity with homologous cytosolic ribosomal proteins. Its applications span basic mitochondrial biology, disease mechanisms, and therapeutic development targeting energy metabolism pathways.
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