| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/100-1/500 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Laminin subunit gamma-3; Laminin 12 gamma 3 subunit; |
| Entrez GeneID | 10319; |
| WB Predicted band size | 172kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human LAMC3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于LAMC3抗体的研究文献摘要(信息基于真实研究领域知识模拟，具体文献请以实际数据库检索结果为准)：
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1. **文献名称**: *LAMC3 mutations cause cortical dysplasia through disordered neuronal migration*
**作者**: Barak T, et al.
**摘要**: 本研究首次发现LAMC3基因突变与人类脑皮质发育畸形相关，通过Western blot和免疫组化技术使用LAMC3抗体证实突变导致γ3链蛋白表达异常，影响神经元迁移和皮层分层。
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2. **文献名称**: *Laminin γ3 (LAMC3) expression in glioblastoma promotes tumor invasion*
**作者**: Zhou W, et al.
**摘要**: 利用LAMC3特异性抗体进行组织染色，发现胶质母细胞瘤中LAMC3高表达与患者预后不良相关，其通过激活整合素信号通路促进肿瘤细胞侵袭，提示其作为治疗靶点潜力。
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3. **文献名称**: *Antibody-based profiling of laminin isoforms in diabetic nephropathy*
**作者**: Kim J, Suzuki K.
**摘要**: 研究采用多种层粘连蛋白亚基抗体(包括LAMC3)分析糖尿病肾病模型，发现LAMC3在肾小球基底膜异常沉积，可能与肾脏纤维化进程相关。
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注：以上文献名为示例性模拟，实际文献需通过PubMed/Google Scholar检索确认。建议使用关键词"LAMC3 antibody"或"LAMC3 laminin"在学术数据库获取最新研究。
The LAMC3 antibody targets the laminin gamma-3 chain, a key component of laminin-332 (formerly laminin-5), a heterotrimeric glycoprotein in the extracellular matrix (ECM). Laminins play critical roles in cell adhesion, differentiation, and tissue organization by bridging cell surface receptors (e.g., integrins) and structural ECM proteins. The gamma-3 chain, encoded by the *LAMC3* gene, is predominantly expressed in epithelial tissues, the nervous system, and during embryonic development. It contributes to the unique functional properties of laminin-332. which is essential for basement membrane integrity and epithelial-stromal interactions.
LAMC3 antibodies are widely used in research to study tissue morphogenesis, wound healing, and cancer biology, as laminin-332 dysfunction is linked to pathologies like epidermolysis bullosa and tumor metastasis. These antibodies enable the detection of LAMC3 in immunoassays (e.g., Western blot, immunohistochemistry) and help elucidate its role in cell signaling, migration, and ECM remodeling. Commercial LAMC3 antibodies are typically raised in rabbits or mice, validated for specificity against recombinant or native proteins.
Recent studies also explore LAMC3's potential as a biomarker in cancers, where its altered expression may correlate with prognosis or therapeutic response. However, challenges remain in standardizing antibody performance across experimental models, necessitating careful validation for reproducible results. Overall, LAMC3 antibodies are vital tools for advancing understanding of ECM biology and its implications in health and disease.
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