Rabbit Polyclonal GA45G Antibody

The GA45G antibody is a monoclonal antibody primarily recognized for its application in cancer research, particularly in the study of epithelial malignancies. It targets a specific epitope associated with intracellular antigens expressed in proliferating cells, such as certain cytokeratins or cell cycle-related proteins, making it a valuable tool for immunohistochemistry (IHC) and immunofluorescence (IF) assays. Originally developed to investigate cellular proliferation and differentiation, GA45G has been widely utilized to identify tumor cells in clinical specimens, aiding in the diagnosis and classification of carcinomas, including breast, lung, and gastrointestinal cancers. Its specificity for epitopes preserved in formalin-fixed, paraffin-embedded tissues enhances its utility in routine pathology workflows. Studies have also explored its potential in prognostic assessments, as overexpression of its target antigens often correlates with aggressive tumor behavior. While its exact molecular target varies depending on the context (e.g., cytokeratin variants or other proliferation markers), GA45G remains a reliable reagent due to its consistent staining patterns and compatibility with automated platforms. Recent advancements in multiplex staining and digital pathology have further expanded its role in translational research, supporting efforts to unravel tumor heterogeneity and therapy resistance mechanisms.