Rabbit Polyclonal GRID2 Antibody

The GRID2 antibody targets the glutamate receptor ionotropic delta-2 subunit (GluD2), encoded by the GRID2 gene, which is predominantly expressed in cerebellar Purkinje cells. GluD2. a member of the ionotropic glutamate receptor family, plays a critical role in synaptic plasticity, motor coordination, and cerebellar circuit development. Unlike traditional glutamate receptors, GluD2 does not directly mediate fast synaptic transmission but regulates synapse formation and maintenance by interacting with presynaptic neurexins and intracellular scaffolding proteins like PSD-93. Research on GRID2 antibodies has been pivotal in studying neurodegenerative and neurodevelopmental disorders. Mutations or deletions in GRID2 are linked to human conditions such as spinocerebellar ataxia and autism spectrum disorders. In mice, GRID2 knockout models exhibit ataxia and impaired motor learning, underscoring its functional significance. GRID2 antibodies are widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to map GluD2 expression, assess synaptic protein interactions, and investigate disease mechanisms. Recent studies also explore its role beyond the cerebellum, including potential involvement in hippocampal function and neuroinflammation. These antibodies thus serve as essential tools for unraveling GluD2's pathophysiology and therapeutic potential in cerebellar ataxias and related neurological diseases.