| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | fibroblast growth factor receptor substrate 3; FRS2B; FRS2beta; MGC17167; SNT-2 |
| Entrez GeneID | 10817; |
| WB Predicted band size | 54kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human FRS3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于FRS3抗体的3篇文献示例(文献信息为模拟示例，实际需根据真实文献调整)：
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1. **文献名称**: *FRS3 regulates ERK signaling in cancer cell invasion*
**作者**: Smith A, et al.
**摘要**: 本研究利用特异性FRS3抗体，揭示了FRS3蛋白通过调控ERK信号通路促进乳腺癌细胞迁移和侵袭的分子机制。Western blot和免疫荧光实验验证了FRS3在肿瘤组织中的高表达。
2. **文献名称**: *Structural insights into FRS3-FGFR1 interaction*
**作者**: Lee H, et al.
**摘要**: 通过免疫共沉淀(Co-IP)结合FRS3抗体，作者解析了FRS3与FGFR1受体的结合域，并发现其磷酸化位点对下游PI3K/AKT通路的激活至关重要。
3. **文献名称**: *FRS3 antibody development for neurodegenerative disease studies*
**作者**: Chen R, et al.
**摘要**: 报道了一种新型高亲和力FRS3单克隆抗体的开发，验证了其在脑组织样本中的特异性，并发现FRS3在阿尔茨海默病模型中的表达异常可能与tau蛋白病理相关。
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**备注**：以上为模拟文献，实际引用时需检索PubMed、Google Scholar等平台，使用关键词“FRS3 antibody”、“FRS3 function”或结合疾病名称(如癌症、神经疾病)筛选近年研究。若文献较少，可扩展至FRS家族(如FRS2)相关研究作为参考。
The FRS3 (Fibroblast Growth Factor Receptor Substrate 3) antibody is a tool used to study the FRS3 protein, a key adaptor molecule in intracellular signaling pathways. FRS3. also known as FRS2β, belongs to the FRS/FRS2 family and shares structural homology with FRS2α, including an N-terminal myristoylation site for membrane anchoring, multiple tyrosine phosphorylation sites, and a C-terminal PTB domain for receptor binding. It primarily mediates signaling downstream of fibroblast growth factor receptors (FGFRs) and neurotrophic receptor tyrosine kinases (e.g., TrkA). Upon receptor activation, FRS3 undergoes tyrosine phosphorylation, creating docking sites for downstream effectors like Grb2 and SOS, which activate RAS-MAPK and PI3K-AKT pathways, regulating cell proliferation, differentiation, and survival.
Compared to FRS2α, FRS3 is less studied but exhibits distinct expression patterns, particularly in neural and endocrine tissues. Research using FRS3 antibodies has highlighted its role in neuronal development, metabolic regulation, and tumorigenesis. For example, FRS3 knockout studies suggest its involvement in glucose homeostasis and insulin sensitivity. In cancer, aberrant FRS3 expression or phosphorylation may contribute to resistance to targeted therapies. The antibody is essential for detecting FRS3 in techniques like Western blotting, immunofluorescence, and immunohistochemistry, enabling investigations into its tissue distribution, post-translational modifications, and interaction networks. Despite its functional overlap with FRS2α, FRS3’s unique roles in specific biological contexts continue to drive antibody-based research.
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