| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CP4X1; CYPIVX1; Cytochrome P450 4X1; EC 1.14.14.1; |
| Entrez GeneID | 260293; |
| WB Predicted band size | 50kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human Cytochrome P450 4X1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于 **Cytochrome P450 4X1 抗体**(假设存在拼写误差，可能为 CYP4X1 或类似亚型)的示例参考文献及摘要概括(文献为虚构示例，仅供参考)：
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1. **文献名称**: "Characterization of a Novel Polyclonal Antibody Against Cytochrome P450 4X1: Implications for Pulmonary Hypertension"
**作者**: Smith A, et al.
**摘要**: 本研究开发并验证了一种针对人源 CYP4X1 酶的多克隆抗体，通过免疫印迹和免疫组化证实其特异性。该抗体在肺高压模型中检测到 CYP4X1 的异常表达，提示其可能参与血管重塑调控。
2. **文献名称**: "Role of CYP4X1 in Lipid Metabolism: Insights from a Monoclonal Antibody-Based Study"
**作者**: Johnson R, et al.
**摘要**: 利用新开发的小鼠单克隆抗体，作者发现 CYP4X1 在肝脏脂质氧化中起关键作用。抗体特异性通过基因敲除模型验证，为代谢综合征研究提供工具。
3. **文献名称**: "Cytochrome P450 4X1 Antibody Localization in Human Brain Tumors"
**作者**: Lee H, et al.
**摘要**: 通过免疫荧光染色结合抗 CYP4X1 抗体，研究揭示了该酶在胶质母细胞瘤中的高表达，提示其可能与肿瘤微环境中的氧感知通路相关。
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**备注**：
- "Cytochrome P454X1" 可能是笔误，实际应为 **CYP4X1** 或其他 CYP450 家族成员(如 CYP3A4、CYP2D6 等)。
- 若需真实文献，建议通过 PubMed 或 Google Scholar 检索 **"Cytochrome P450 4X1 antibody"** 或相关关键词，并核实名称准确性。
Cytochrome P450 4X1 (CYP4X1) is a member of the cytochrome P450 enzyme superfamily, which plays a critical role in metabolizing endogenous and exogenous compounds, including drugs, fatty acids, and signaling molecules. CYP4X1 is a poorly characterized isoform, though studies suggest its involvement in vascular homeostasis, neuroprotection, and tumor angiogenesis. It is expressed in various tissues, including the brain, endothelium, and certain cancers. Its enzymatic activity is linked to the oxidation of fatty acids, potentially influencing inflammatory responses and cellular proliferation.
Antibodies targeting CYP4X1 are essential tools for investigating its expression, localization, and functional roles. These antibodies are typically developed using immunogenic peptide sequences or recombinant protein fragments, validated for specificity via Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF). Research applications include studying CYP4X1's regulation under pathological conditions, such as cancer progression, neurological disorders, or cardiovascular diseases. For instance, upregulated CYP4X1 in glioblastoma or endothelial cells has been associated with pro-angiogenic effects, highlighting its potential as a therapeutic target. However, due to limited functional data, the antibody also serves as a crucial reagent for elucidating CYP4X1's substrate specificity, tissue distribution, and interaction networks. Challenges remain in distinguishing cross-reactivity with other P450 isoforms, emphasizing the need for rigorous validation in experimental models.
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