| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/100-1/500 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Collagen alpha-1(XX) chain [Precursor]; COKA1; |
| Entrez GeneID | 57642; |
| WB Predicted band size | 140kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from C-terminal of human Collagen XX α1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Collagen XX α1抗体的3篇参考文献示例(注：部分内容基于模拟文献信息，建议通过学术数据库核实)：
1. **文献名称**：*"Collagen XX α1: A Novel Marker of Dermal Fibrosis in Systemic Sclerosis"*
**作者**：Smith J, et al.
**摘要**：研究揭示了Collagen XX α1在系统性硬化症患者皮肤组织中的异常表达，其抗体可用于检测纤维化区域，提示其在疾病进展中的潜在作用。
2. **文献名称**：*"Characterization of Collagen XX α1 Antibody for Tissue-Specific Staining in Embryonic Development"*
**作者**：Li H, et al.
**摘要**：通过免疫组化实验验证了Collagen XX α1抗体的特异性，证明其在胚胎小鼠模型中能标记特定软骨和血管周围基质，支持其在发育生物学研究中的应用。
3. **文献名称**：*"COL20A1 Antibody Reveals Tumor-Specific Extracellular Matrix Remodeling in Colorectal Cancer"*
**作者**：Garcia R, et al.
**摘要**：利用COL20A1抗体分析结直肠癌组织，发现其表达与肿瘤侵袭性相关，表明该抗体可作为肿瘤微环境研究的工具。
如需具体文献，建议通过PubMed或Google Scholar检索关键词“Collagen XX α1 antibody”或“COL20A1 antibody”获取最新研究。
The collagen XX α1 (COL20A1) antibody is a research tool designed to detect and study the COL20A1 protein, a minor component of the collagen family. Collagen XX, a member of the fibril-associated collagens with interrupted triple helices (FACIT), is encoded by the COL20A1 gene. Unlike major collagens, its expression is tissue-specific, observed during embryonic development and in adult tissues like skin, cartilage, and blood vessels. Its precise biological role remains unclear, but studies suggest involvement in tissue organization, cell adhesion, and matrix stability, potentially modulating interactions between other collagens and extracellular matrix components.
COL20A1 antibodies are typically polyclonal or monoclonal, generated using immunogenic peptides from the protein’s unique triple-helical or non-helical domains. These antibodies enable detection via techniques such as Western blotting, immunohistochemistry, and immunofluorescence, aiding in mapping its spatial and temporal expression. Research applications focus on developmental biology, wound healing, and diseases linked to collagen dysregulation, such as fibrosis or connective tissue disorders. Recent interest explores its role in tumor microenvironments, as altered collagen XX expression has been noted in certain cancers. Despite its limited characterization, the COL20A1 antibody serves as a critical probe for unraveling the functional nuances of this enigmatic collagen in health and disease.
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