Rabbit Polyclonal CNTD2 Antibody

The CNTD2 (Cyclin N-Terminal Domain-Containing Protein 2) antibody is a tool used to study the CNTD2 protein, a member of the cyclin family involved in cell cycle regulation. CNTD2 is known for its role in promoting cell cycle progression, particularly during the G1/S phase transition, by interacting with cyclin-dependent kinases (CDKs). Structurally, it contains a conserved cyclin domain that facilitates protein-protein interactions, notably with CDK2. to modulate downstream signaling pathways. Dysregulation of CNTD2 has been implicated in various cancers, including breast, liver, and colorectal cancers, where its overexpression correlates with tumor proliferation, poor prognosis, and therapeutic resistance. Research suggests CNTD2 may influence genomic stability and DNA repair mechanisms, potentially through associations with E3 ubiquitin ligases. Antibodies targeting CNTD2 are essential for detecting its expression and localization in tissues or cell lines via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies aid in elucidating CNTD2's functional roles in oncogenesis and its potential as a diagnostic biomarker or therapeutic target. Recent studies also explore its involvement in non-cancer contexts, such as developmental processes. However, the precise molecular mechanisms and regulatory networks remain under investigation, highlighting the need for high-specificity antibodies to advance CNTD2-related research.