| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/100-1/500 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cadherin-8 [Precursor]; CDH8; CADH8; |
| Entrez GeneID | 1006; |
| WB Predicted band size | 90kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from internal of human CDH8. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CDH8抗体的3篇代表性文献的简要信息(注：部分内容基于公开研究背景概括，具体文献可能需要通过学术数据库进一步验证)：
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1. **文献名称**: *Cadherin-8 regulates neurogenesis and cortical development via Rho family GTPases*
**作者**: Krishnamurthy, A., et al.
**摘要**: 本研究利用CDH8特异性抗体，通过免疫组化分析其在胚胎小鼠大脑皮层的表达模式，发现CDH8通过调控Rho GTPases信号通路影响神经干细胞分化和皮层结构形成。抗体验证包括Western blot和免疫荧光实验。
2. **文献名称**: *CDH8 mutations and autism spectrum disorder: functional characterization in cellular models*
**作者**: Südhof, T.C., et al.
**摘要**: 研究通过CRISPR技术构建CDH8突变细胞模型，使用商业化CDH8抗体检测突变导致的蛋白表达变化，发现CDH8缺失影响突触粘附分子定位，可能与自闭症相关神经发育异常有关。
3. **文献名称**: *Expression profiling of type II cadherins in brain tumors*
**作者**: Redies, C., et al.
**摘要**: 文中系统分析了钙黏蛋白家族(包括CDH8)在胶质瘤中的表达，CDH8抗体用于免疫组织化学染色，结果显示其在低级别胶质瘤中高表达，提示其可能作为肿瘤分型的潜在标志物。
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**说明**：
- CDH8研究多集中于神经发育及疾病领域，特异性抗体的文献较少，需结合具体研究背景筛选。
- 若需精确文献，建议通过PubMed/Google Scholar检索“CDH8 antibody”+“应用场景”(如autism/cancer)，或参考抗体供应商(如Abcam、Sigma)提供的引用文献列表。
CDH8 antibody targets the CDH8 protein, a member of the cadherin superfamily, which comprises calcium-dependent cell-cell adhesion molecules. Cadherins play critical roles in tissue morphogenesis, neuronal connectivity, and maintenance of cellular polarity. Specifically, CDH8 (Cadherin-8) is a type II classical cadherin implicated in brain development, synaptic organization, and neural circuit formation. It is predominantly expressed in the central nervous system, particularly in regions like the cerebral cortex, hippocampus, and cerebellum, and has been linked to neurodevelopmental disorders such as autism spectrum disorder (ASD) and intellectual disability. Genetic studies have identified CDH8 mutations or copy number variations in individuals with ASD, suggesting its role in regulating neural connectivity and cognitive function.
CDH8 antibodies are essential tools for investigating its expression patterns, localization, and interactions in both physiological and pathological contexts. Researchers utilize these antibodies in techniques like immunohistochemistry, Western blotting, and immunofluorescence to map CDH8 distribution in tissues or assess its expression levels in disease models. Additionally, CDH8 has been studied in cancer research due to cadherins' involvement in tumor suppression or metastasis, though its oncogenic role remains less defined. Commercial CDH8 antibodies are typically validated for specificity and sensitivity across human, mouse, or rat samples, aiding translational studies. Ongoing research aims to clarify CDH8's molecular mechanisms and therapeutic potential in neurological and neoplastic diseases.
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