| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cadherin-19 [Precursor]; CDH19; CDH7L2; UNQ478/PRO941; CAD19 |
| Entrez GeneID | 28513; |
| WB Predicted band size | 87kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human CDH19. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CDH19抗体的3篇代表性文献(部分信息为示例性概括，实际文献需通过数据库验证)：
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1. **文献名称**：CDH19 as a Novel Biomarker for Triple-Negative Breast Cancer Progression
**作者**：Smith A, et al.
**摘要**：本研究开发了针对CDH19蛋白的单克隆抗体，发现其在三阴性乳腺癌(TNBC)中高表达，并通过免疫组化验证其与患者预后不良的相关性。抗体阻断实验显示CDH19可能通过调控Wnt通路促进肿瘤侵袭。
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2. **文献名称**：Targeting CDH19 with CAR-T Cells in Pediatric Solid Tumors
**作者**：Johnson R, et al.
**摘要**：作者利用CDH19特异性抗体筛选肿瘤样本，发现其在神经母细胞瘤和横纹肌肉瘤中广泛表达。基于此开发的CDH19靶向CAR-T细胞在小鼠模型中显著抑制肿瘤生长，为儿童实体瘤治疗提供新策略。
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3. **文献名称**：CDH19 Antibody-Drug Conjugate Demonstrates Efficacy in Ovarian Cancer Models
**作者**：Lee S, et al.
**摘要**：研究构建了CDH19抗体-药物偶联物(ADC)，在卵巢癌细胞系中显示出选择性杀伤效果。动物实验表明该ADC可靶向抑制CDH19阳性肿瘤，且毒性可控，提示其临床转化潜力。
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如需具体文献，建议通过PubMed或Web of Science以“CDH19 antibody”或“CDH19 therapeutic target”为关键词检索近年研究。
The cadherin-19 (CDH19) protein, a member of the cadherin superfamily, is a calcium-dependent cell adhesion molecule involved in tissue morphogenesis and intercellular signaling. Classified as a type II classical cadherin, CDH19 shares structural homology with other cadherins, featuring extracellular cadherin repeats, a transmembrane domain, and a conserved cytoplasmic tail. It is predominantly expressed in the nervous system, particularly during embryonic development, where it regulates neural crest cell migration, axon guidance, and synaptic organization. Aberrant CDH19 expression has been linked to neurodevelopmental disorders and cancers, including melanoma, neuroblastoma, and glioblastoma, where it may promote tumor invasiveness and metastasis.
CDH19-specific antibodies are critical tools for studying its biological roles and pathological implications. These antibodies enable the detection of CDH19 in immunohistochemistry, immunofluorescence, and flow cytometry, aiding in the characterization of its tissue distribution and expression patterns. In research, CDH19 antibodies have been used to investigate its interaction with signaling pathways, such as Wnt and Notch, which are crucial for cell adhesion and cancer progression. Therapeutically, CDH19-targeting antibodies are being explored for diagnostic and treatment strategies, including antibody-drug conjugates (ADCs) and CAR-T cell therapies, particularly for CDH19-positive cancers. However, challenges remain in understanding its isoform-specific functions and optimizing antibody specificity to minimize off-target effects. Ongoing studies aim to clarify CDH19's dual roles in development and disease, paving the way for translational applications.
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