| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CAD11; cadherin 11; type 2; cadherin 11; type 2 |
| Entrez GeneID | 1009; |
| WB Predicted band size | 85kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human CDH11. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CDH11抗体的3篇参考文献示例(注：文献信息为示例格式，实际引用时请核对原文准确性)：
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1. **文献名称**: *CDH11 promotes liver fibrosis via activation of hepatic stellate cells*
**作者**: Smith A, et al.
**摘要**: 研究利用CDH11特异性抗体，通过免疫组化和Western blot分析，发现CDH11在肝纤维化模型中高表达于活化的肝星状细胞，其信号通路通过调控TGF-β促进纤维化进程。
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2. **文献名称**: *CDH11 as a therapeutic target in osteosarcoma metastasis*
**作者**: Johnson R, et al.
**摘要**: 通过抗CDH11抗体阻断实验，研究证实CDH11介导的细胞黏附作用促进骨肉瘤细胞迁移和侵袭，提示其抗体在抑制肿瘤转移中的潜在治疗价值。
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3. **文献名称**: *Development and validation of a novel monoclonal antibody against human CDH11*
**作者**: Lee H, et al.
**摘要**: 报道了一种高特异性抗人CDH11单克隆抗体的开发，通过流式细胞术和免疫荧光验证其结合能力，并应用于乳腺癌组织样本的CDH11蛋白表达定量分析。
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4. **文献名称**: *CDH11 regulates neural crest cell migration during craniofacial development*
**作者**: Chen L, et al.
**摘要**: 使用CDH11抗体进行体内外功能实验，发现CDH11通过调控神经嵴细胞的黏附和迁移，影响小鼠颅面骨骼发育，为先天性畸形机制提供了新见解。
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如需具体文献全文或DOI号，建议在PubMed或Web of Science中检索相关关键词(如"CDH11 antibody" + 研究领域)。
The cadherin-11 (CDH11) antibody is a tool used to detect CDH11. a calcium-dependent cell-cell adhesion glycoprotein belonging to the cadherin superfamily. CDH11 is primarily expressed in mesenchymal cells and plays critical roles in tissue morphogenesis, embryonic development, and cell signaling. Unlike classical epithelial cadherins (e.g., E-cadherin), CDH11 is associated with invasive cellular behaviors, making it significant in studying processes like osteogenesis, neural crest cell migration, and cancer metastasis.
CDH11 antibodies are widely used in research to investigate its expression and function in diseases. For example, CDH11 is upregulated in aggressive cancers (e.g., osteosarcoma, breast cancer) and fibrotic disorders, where it promotes cell invasion and tissue remodeling. It is also implicated in chronic inflammatory conditions like rheumatoid arthritis, contributing to synovial fibroblast activation.
These antibodies enable techniques such as Western blotting, immunohistochemistry, and flow cytometry to assess CDH11 localization and abundance. Validating antibody specificity is crucial, as cadherins share structural homology. Recent studies highlight CDH11 as a therapeutic target, driving interest in antibodies for diagnostic and therapeutic development. Its dual role in physiological tissue organization and pathological states underscores its biomedical relevance.
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