| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L; PCAF-associated factor 65 alpha; PAF65-alpha; TAF6L; PAF65A |
| Entrez GeneID | 10629; |
| WB Predicted band size | 68kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human TAF6L. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于TAF6L抗体的参考文献(示例基于虚构内容，实际文献需通过学术数据库检索确认)：
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1. **文献名称**: *TAF6L regulates embryonic stem cell pluripotency through chromatin remodeling*
**作者**: Wei, G., et al.
**摘要**: 该研究使用TAF6L特异性抗体进行ChIP-seq分析，发现TAF6L通过结合启动子区域调控多能性基因(如Oct4、Nanog)，维持胚胎干细胞的自我更新能力。
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2. **文献名称**: *TAF6L deficiency promotes apoptosis via p53 pathway activation*
**作者**: Rodriguez, M., & Smith, J.
**摘要**: 通过TAF6L抗体进行Western blot和免疫荧光实验，发现敲低TAF6L导致p53蛋白稳定性增加，激活下游促凋亡基因(如BAX)，提示其在DNA损伤应答中的关键作用。
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3. **文献名称**: *TAF6L as a prognostic biomarker in colorectal cancer*
**作者**: Tanaka, H., et al.
**摘要**: 利用TAF6L抗体对结直肠癌组织进行免疫组化分析，发现高表达TAF6L与患者生存率负相关，提示其可能作为治疗靶点或预后标志物。
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如需具体文献，建议在PubMed或Google Scholar中检索“TAF6L antibody”及关联研究领域(如染色质调控、癌症、凋亡)。部分实际研究可能未直接以TAF6L抗体为核心，但在方法学中提及抗体应用。
The TAF6L (TATA-box binding protein-associated factor 6-like) antibody is a research tool used to study the role of TAF6L, a component of the transcription factor IID (TFIID) complex, which is critical for RNA polymerase II-mediated gene transcription. TAF6L, also known as TAFII70 or TAFII80. shares homology with TAF6 but is expressed from a distinct gene. It plays a regulatory role in transcription initiation by interacting with other TFIID subunits and facilitating the assembly of the pre-initiation complex at promoter regions. TAF6L is involved in specific transcriptional programs, including stem cell maintenance, differentiation, and apoptosis, and has been implicated in diseases such as cancer.
Antibodies targeting TAF6L are widely used in molecular biology to investigate its expression, localization, and interactions. They enable techniques like Western blotting, immunoprecipitation, and immunofluorescence to assess protein levels in various cell types or under experimental conditions (e.g., stress, differentiation). Studies using TAF6L antibodies have revealed its tissue-specific expression patterns and regulatory roles in developmental pathways. Additionally, research links TAF6L dysfunction to oncogenesis, making it a potential biomarker or therapeutic target. Commercial TAF6L antibodies are typically validated for specificity via knockout/knockdown controls to ensure accurate detection in experimental models.
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