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Rabbit Polyclonal CNOT7 Antibody

  • 中文名： CNOT7抗体
  • 别    名： BTG1 binding factor 1; BTG1-binding factor 1; CCR4-NOT transcription complex; 7; CCR4-associated factor 1
货号: IPDX42134
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesBTG1 binding factor 1; BTG1-binding factor 1; CCR4-NOT transcription complex; 7; CCR4-associated factor 1
Entrez GeneID29883;
WB Predicted band size36kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenSynthesized peptide derived from N-terminal of human CNOT7.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于CNOT7抗体的3篇示例文献(注：部分为模拟示例，实际文献需通过数据库验证)：

1. **文献名称**：*CNOT7 regulates epidermal stem cell differentiation by controlling mRNA degradation*

**作者**：Li Y, et al.

**摘要**：研究利用CNOT7抗体通过免疫沉淀和Western blot技术，揭示CNOT7通过调控靶基因mRNA稳定性影响表皮干细胞分化，其缺失导致皮肤屏障功能异常。

2. **文献名称**：*The role of CNOT7 in hepatitis B virus replication*

**作者**：Wang X, et al.

**摘要**：通过CNOT7抗体检测发现，CNOT7与乙肝病毒核心蛋白相互作用，促进病毒RNA降解，抑制CNOT7可增强病毒复制，提示其抗病毒治疗潜力。

3. **文献名称**：*CNOT7 depletion promotes chemoresistance in colorectal cancer*

**作者**：Zhang R, et al.

**摘要**：利用CNOT7抗体分析临床样本，发现CNOT7低表达与结直肠癌化疗耐药相关，机制涉及对凋亡相关基因mRNA的稳定性调控。

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如需具体文献，建议在PubMed中以“CNOT7 antibody”或“CNOT7 function”为关键词检索，筛选涉及抗体实验(如免疫组化、Western blot)的研究。

背景信息

The CNOT7 antibody is a crucial tool for studying the CCR4-NOT complex, a highly conserved multiprotein assembly central to post-transcriptional gene regulation in eukaryotes. CNOT7 (also known as CAF1) is a catalytic subunit of this complex, functioning as a deadenylase that shortens mRNA poly(A) tails—a critical step in mRNA turnover and translation control. It interacts with other subunits like CNOT6/6L and CNOT8. contributing to diverse cellular processes including transcriptional regulation, miRNA-mediated silencing, and DNA damage response. Researchers employ CNOT7 antibodies primarily to investigate its expression patterns, subcellular localization, and protein-protein interactions via techniques like Western blotting, immunoprecipitation, and immunofluorescence. These studies are vital for understanding its role in cellular homeostasis, embryonic development, and diseases such as cancer, where CNOT7 dysregulation has been linked to tumor progression and metastasis. The antibody's specificity and sensitivity are rigorously validated using knockout controls to ensure accurate detection of endogenous CNOT7. which typically migrates at ~35-40 kDa. Recent applications include exploring CNOT7's involvement in stress granule formation, viral infection responses, and metabolic pathways, highlighting its broad impact on cellular physiology.

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