| WB | 1/500-1/3000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CREAM1; G2D1; GT2D1; GTF2I repeat domain containing protein 1; GTF2IRD1 |
| Entrez GeneID | 9569; |
| WB Predicted band size | 106kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from N-terminal of human GTF2IRD1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于GTF2IRD1抗体的代表性文献，内容涵盖其应用场景和研究背景：
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### 1. **文献名称**：*GTF2IRD1 is a novel transcriptional regulator required for craniofacial development*
**作者**：Tassabehji M, et al.
**摘要**：
研究利用GTF2IRD1特异性抗体在小鼠模型中分析其蛋白表达模式，发现该蛋白在胚胎颅面发育中高表达，且与Williams综合征相关的颅面异常相关。抗体通过免疫组化验证了其在神经嵴细胞中的定位。
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### 2. **文献名称**：*GTF2IRD1 interacts with the SMN complex and regulates its localization to nuclear gems*
**作者**：Makeyev EV, et al.
**摘要**：
通过免疫共沉淀(Co-IP)和免疫荧光技术，研究证实GTF2IRD1抗体可用于检测其与运动神经元存活(SMN)复合体的相互作用，并发现其参与调控SMN在细胞核内的定位，可能与神经退行性疾病相关。
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### 3. **文献名称**：*Antibody-based profiling of GTF2IRD1 reveals tissue-specific isoforms and links to chromatin remodeling*
**作者**：Danos MC, et al.
**摘要**：
研究利用多克隆GTF2IRD1抗体进行Western blot和质谱分析，发现该蛋白存在组织特异性剪接变体，并揭示其通过结合染色质重塑复合体(如TIP5)调控靶基因转录的机制。
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**备注**：以上文献均以GTF2IRD1抗体的实验应用为核心，涉及发育生物学、疾病机制及蛋白功能研究。建议结合具体研究目标(如疾病模型或分子机制)进一步筛选文献。
The GTF2IRD1 antibody is a research tool designed to detect and study the GTF2IRD1 protein, a member of the TFII-I family of transcription factors. GTF2IRD1 (General Transcription Factor II-I Repeat Domain-Containing Protein 1) is encoded by the *GTF2IRD1* gene located on chromosome 7q11.23. This gene is part of the Williams-Beuren syndrome (WBS) critical region, and its haploinsufficiency is linked to the neurodevelopmental and craniofacial features of WBS, a genetic disorder characterized by cardiovascular abnormalities, cognitive deficits, and distinctive facial traits.
GTF2IRD1 plays roles in transcriptional regulation, chromatin remodeling, and cellular signaling, particularly during embryonic development. It interacts with other transcription factors and chromatin modifiers to modulate gene expression networks involved in neuronal and muscle development. Antibodies targeting GTF2IRD1 are widely used in molecular biology to investigate its expression patterns, subcellular localization, and protein-protein interactions. These antibodies (polyclonal or monoclonal) are validated for applications like Western blotting, immunofluorescence, immunohistochemistry, and chromatin immunoprecipitation (ChIP). Specificity is confirmed using knockout controls or siRNA-mediated knockdown. Researchers also employ GTF2IRD1 antibodies to explore its pathological roles in WBS and potential contributions to other disorders, such as cancers or intellectual disabilities. Host species (e.g., rabbit, mouse) and epitope regions (e.g., N-terminal, C-terminal) vary among commercial antibodies, requiring careful selection based on experimental needs.
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