| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger transcription factor Trps1; Zinc finger protein GC79; Tricho-rhino-phalangeal syndrome type I protein; TRPS1; |
| Entrez GeneID | 7227; |
| WB Predicted band size | 142kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from N-terminal of human TRPS1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3-4条关于TRPS1抗体的参考文献及其简要摘要：
1. **《TRPS1 is a lineage-specific transcriptional dependency in breast cancer》**
- **作者**: A. H. Adamo et al.
- **摘要**: 本研究验证了TRPS1抗体在乳腺癌中的特异性表达，证实TRPS1作为乳腺上皮细胞分化的关键调控因子，其抗体在免疫组化中可有效区分乳腺源性肿瘤与其他组织来源的癌症。
2. **《TRPS1 as a marker for triple-negative breast cancer: a comparative immunohistochemical study》**
- **作者**: G. Krings & Y. Y. Chen
- **摘要**: 通过对比多种乳腺癌亚型，研究发现TRPS1抗体在三阴性乳腺癌(TNBC)中呈现高敏感性和特异性，提示其可作为TNBC诊断及鉴别的重要辅助标记物。
3. **《Utility of TRPS1 immunohistochemistry in diagnosis of metastatic breast carcinoma》**
- **作者**: J. L. Hornick & E. D. Rossi
- **摘要**: 文章评估了TRPS1抗体在转移性乳腺癌中的诊断价值，结果显示其相较于GATA3等其他标记物，在鉴别乳腺原发与转移性肿瘤中具有更高的特异性，尤其适用于肺、骨等转移灶的溯源。
4. **《TRPS1 expression in salivary gland and skin adnexal neoplasms: a potential diagnostic pitfall》**
- **作者**: K. J. Busam & M. M. Baine
- **摘要**: 研究指出，尽管TRPS1抗体对乳腺癌具有高度特异性，但在某些唾液腺和皮肤附件肿瘤中也可能呈阳性，提示诊断时需结合临床与其他标记物以避免误判。
**注**：以上文献名为示例性内容，实际引用时需根据具体论文调整标题及作者信息。
The TRPS1 antibody targets the protein encoded by the TRPS1 gene, a transcriptional repressor involved in regulating cell proliferation, differentiation, and development. TRPS1 (Trichorhinophalangeal Syndrome Type 1) is named for its association with a rare autosomal dominant disorder characterized by craniofacial, skeletal, and hair abnormalities. Structurally, TRPS1 contains multiple zinc-finger domains, including a GATA-type zinc finger that mediates DNA binding and interaction with other transcriptional regulators. It represses gene expression by recruiting chromatin-modifying complexes, such as histone deacetylases (HDACs), and plays roles in bone, cartilage, and hair follicle development.
In research and diagnostics, TRPS1 antibodies are widely used to study its expression and function in cancers, particularly breast cancer. TRPS1 has emerged as a sensitive marker for breast carcinomas, especially triple-negative breast cancer (TNBC), aiding in differential diagnosis and subtyping. Its nuclear expression helps distinguish breast origin from other malignancies, complementing markers like GATA3. Beyond oncology, TRPS1 antibodies are utilized to explore its role in skeletal disorders and developmental pathways. Recent studies also investigate its potential as a therapeutic target or biomarker for treatment response. However, variability in antibody specificity and staining protocols necessitates careful validation in experimental and clinical settings.
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