Rabbit Polyclonal ZC3H7B Antibody

ZC3H7B antibody targets the ZC3H7B protein, a member of the zinc finger CCCH-type domain-containing protein family. These proteins are characterized by their conserved CCCH zinc finger motifs, which enable RNA binding and participation in post-transcriptional gene regulation. ZC3H7B, also known as Roquin2. plays roles in immune homeostasis, mRNA stability, and turnover, particularly in regulating inflammatory responses. It interacts with mRNA decay machinery and controls transcripts involved in T-cell activation and cytokine signaling. Dysregulation of ZC3H7B has been linked to autoimmune disorders and cancer. Antibodies against ZC3H7B are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate its regulatory mechanisms in cellular and disease contexts. Commercial ZC3H7B antibodies are typically developed in rabbits or mice using immunogenic peptide sequences specific to conserved regions of the protein. Validation includes testing for specificity via knockout cell lines or siRNA-mediated knockdown. Research utilizing these antibodies has advanced understanding of ZC3H7B's dual roles in RNA metabolism and immune regulation, highlighting its potential as a therapeutic target in inflammation-related pathologies.