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Rabbit Polyclonal ZC3H7B Antibody

  • 中文名： ZC3H7B抗体
  • 别    名： KIAA1031; ROXN; Rotavirus 'X' associated non-structural protein; Z3H7B; ZC3H7B
货号: IPDX42128
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/500-1/3000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesKIAA1031; ROXN; Rotavirus 'X' associated non-structural protein; Z3H7B; ZC3H7B
Entrez GeneID23264;
WB Predicted band size111kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthesized peptide derived from internal of human ZC3H7B.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3-4条关于ZC3H7B抗体的假设性参考文献示例(注：以下内容为模拟生成，非真实文献)：

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1. **文献名称**: *ZC3H7B regulates mRNA stability in T-cell activation through specific RNA binding*

**作者**: Müller, S. et al.

**摘要**: 本研究利用ZC3H7B抗体进行免疫共沉淀和Western blot分析，发现ZC3H7B蛋白通过结合T细胞活化相关基因的3'UTR区域调控mRNA稳定性，影响免疫应答进程。

2. **文献名称**: *Aberrant expression of ZC3H7B in hepatocellular carcinoma detected by immunohistochemistry*

**作者**: Li, X. & Wang, Y.

**摘要**: 通过抗ZC3H7B抗体的免疫组化实验，证实ZC3H7B在肝癌组织中表达显著下调，且低表达与患者预后不良相关，提示其可能作为肿瘤抑制因子发挥作用。

3. **文献名称**: *Subcellular localization of ZC3H7B in neuronal cells under oxidative stress*

**作者**: Gonzalez, R. et al.

**摘要**: 采用ZC3H7B特异性抗体进行免疫荧光染色，发现该蛋白在神经元氧化应激条件下从细胞核转位至胞质，可能与应激颗粒形成及RNA保护机制有关。

4. **文献名称**: *ZC3H7B interacts with the CCR4-NOT complex: Evidence from co-immunoprecipitation assays*

**作者**: Tanaka, K. et al.

**摘要**: 通过ZC3H7B抗体介导的免疫共沉淀实验，证实其与CCR4-NOT去腺苷酸化复合体相互作用，揭示了其在转录后调控中的新机制。

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注：以上文献为示例性内容，实际研究中请通过PubMed、Google Scholar等平台检索真实发表的论文。

背景信息

ZC3H7B antibody targets the ZC3H7B protein, a member of the zinc finger CCCH-type domain-containing protein family. These proteins are characterized by their conserved CCCH zinc finger motifs, which enable RNA binding and participation in post-transcriptional gene regulation. ZC3H7B, also known as Roquin2. plays roles in immune homeostasis, mRNA stability, and turnover, particularly in regulating inflammatory responses. It interacts with mRNA decay machinery and controls transcripts involved in T-cell activation and cytokine signaling. Dysregulation of ZC3H7B has been linked to autoimmune disorders and cancer. Antibodies against ZC3H7B are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate its regulatory mechanisms in cellular and disease contexts. Commercial ZC3H7B antibodies are typically developed in rabbits or mice using immunogenic peptide sequences specific to conserved regions of the protein. Validation includes testing for specificity via knockout cell lines or siRNA-mediated knockdown. Research utilizing these antibodies has advanced understanding of ZC3H7B's dual roles in RNA metabolism and immune regulation, highlighting its potential as a therapeutic target in inflammation-related pathologies.

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