| WB | 1/500-1/3000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | DCI |
| WB Predicted band size | 33 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human ECI1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HEY2抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: "Hey2 regulates the size of the cardiac progenitor pool during vertebrate heart development"
**作者**: Xin M, et al.
**摘要**: 本研究利用HEY2特异性抗体进行免疫组化和Western blot分析，发现HEY2通过调控Notch信号通路限制心脏祖细胞的数量。HEY2缺失导致小鼠胚胎心脏发育异常，提示其在心脏形态发生中的关键作用。
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2. **文献名称**: "Hes and Hey bHLH factors control progenitor cell division in the developing mouse lateral ventricle"
**作者**: Kokubo H, et al.
**摘要**: 通过HEY2抗体的免疫荧光染色，作者揭示了HEY2在小鼠侧脑室神经祖细胞中的时空表达模式，证明其通过抑制细胞周期退出维持祖细胞增殖，影响脑室结构发育。
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3. **文献名称**: "Notch signaling regulates smooth muscle differentiation of epicardium-derived cells"
**作者**: Fischer A, et al.
**摘要**: 该研究使用HEY2抗体检测心外膜来源细胞的蛋白表达，发现Notch信号通过上调HEY2促进平滑肌分化，为心脏修复机制提供了新见解。
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以上文献均以HEY2抗体为工具，探讨了该蛋白在发育生物学中的功能，涵盖心脏、神经系统的研究。如需具体实验细节或引用格式，建议通过PubMed/Google Scholar检索DOI获取全文。
The HEY2 antibody is a tool used to detect and study the HEY2 protein, a member of the HES-related family of basic helix-loop-helix (bHLH) transcription factors. HEY2. also known as HES-related repressor protein 2. plays a critical role in developmental processes, particularly in cardiovascular and nervous systems, by acting downstream of the Notch signaling pathway. It functions as a transcriptional repressor, regulating cell differentiation, tissue morphogenesis, and organogenesis. HEY2 is implicated in heart development, vascular remodeling, and neural crest cell migration, with its dysregulation linked to congenital heart defects, cancers, and vascular diseases.
The HEY2 antibody is widely utilized in research to investigate protein expression patterns, localization, and interactions in cellular and tissue contexts. It is validated for applications like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). Researchers employ this antibody to explore HEY2’s role in gene regulatory networks, developmental biology, and disease mechanisms, particularly in models of cardiac hypertrophy, tumor angiogenesis, and stem cell differentiation. Commercial HEY2 antibodies are typically raised against specific epitopes of human or murine HEY2. with cross-reactivity tested across species. Proper validation, including knockout controls, is essential to ensure specificity due to potential homology with other HEY/HES family members.
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