| WB | 1/500-1/3000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/100-1/500 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Macrophage mannose receptor 2 [Precursor]; Urokinase receptor-associated protein; Endocytic receptor 180; CD280 antigen; MRC2 |
| Entrez GeneID | 9902; |
| WB Predicted band size | 167kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from internal of human MRC2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MRC2抗体的3篇文献参考示例(注：以下内容为模拟生成，非真实文献)：
1. **文献名称**：《Targeting MRC2-expressing macrophages in tumor microenvironment with monoclonal antibody therapy》
**作者**：Zhang L, et al.
**摘要内容**：该研究开发了一种靶向MRC2的单克隆抗体，通过抑制肿瘤相关巨噬细胞的MRC2活性，显著减少小鼠模型中肿瘤的免疫抑制微环境，并增强化疗药物的抗肿瘤效果。
2. **文献名称**：《Development of a high-affinity anti-MRC2 antibody for imaging of fibrosis progression》
**作者**：Martinez R, et al.
**摘要内容**：研究者设计了一种高亲和力的MRC2抗体，结合分子影像技术，成功在小鼠肝纤维化模型中实现早期纤维化病灶的可视化，为无创诊断提供了新工具。
3. **文献名称**：《MRC2 antibody-drug conjugate demonstrates efficacy in metastatic breast cancer models》
**作者**：Kim S, et al.
**摘要内容**：该文献报道了一种基于MRC2抗体的抗体-药物偶联物(ADC)，在乳腺癌转移模型中有效靶向表达MRC2的肿瘤细胞，显著抑制肿瘤生长并减少全身毒性。
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**注**：以上文献为示例，建议通过PubMed或Google Scholar检索关键词“MRC2 antibody”、“anti-Mannose Receptor C-Type 2”获取真实研究。
The MRC2 (Mannose Receptor C-Type 2), also known as CD206 or macrophage mannose receptor, is a transmembrane glycoprotein primarily expressed on macrophages and dendritic cells. It plays a key role in endocytosis, antigen presentation, and immune modulation by recognizing glycoproteins with terminal mannose, fucose, or N-acetylglucosamine residues. Structurally, MRC2 contains multiple domains, including a fibronectin type II domain, cysteine-rich regions, and C-type lectin-like domains, enabling interactions with pathogens, collagen, and other ligands.
Antibodies targeting MRC2 are widely used in research to study macrophage polarization, tumor-associated macrophages (TAMs), and immune responses. In cancer biology, MRC2 is associated with M2-like macrophages, which promote tumor progression, immunosuppression, and angiogenesis. Its expression correlates with poor prognosis in cancers like breast, ovarian, and colorectal carcinoma. MRC2 antibodies enable detection via flow cytometry, immunohistochemistry, and Western blot, aiding in characterizing macrophage subsets in tumor microenvironments or inflammatory diseases. Additionally, MRC2 is implicated in tissue remodeling and fibrosis, making it a potential therapeutic target. Research using these antibodies contributes to understanding MRC2's dual roles in pathogen clearance and disease pathogenesis, bridging innate immunity with chronic inflammatory or malignant conditions.
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