| WB | 1/500-1/3000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Docking protein 5; Downstream of tyrosine kinase 5; Insulin receptor substrate 6; IRS-6; IRS6 |
| Entrez GeneID | 55816; |
| WB Predicted band size | 36kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human DOK5. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于DOK5抗体的3篇参考文献示例(注：内容为虚构概括，仅用于示例)：
1. **标题**：*DOK5 regulates insulin signaling through its interaction with IRS-1*
**作者**：Tanaka K, et al.
**摘要**：研究揭示了DOK5蛋白在胰岛素受体信号通路中的作用，通过特异性抗体验证其与IRS-1的相互作用，表明DOK5可能参与2型糖尿病的病理机制。
2. **标题**：*Development of a monoclonal antibody targeting DOK5 for cancer biomarker studies*
**作者**：Chen L, et al.
**摘要**：报道了一种新型DOK5单克隆抗体的开发，验证了其在肺癌组织中的高特异性结合能力，并探讨DOK5表达与肿瘤转移的相关性。
3. **标题**：*DOK5 phosphorylation modulates neuronal differentiation in vitro*
**作者**：Smith J, et al.
**摘要**：利用抗DOK5抗体研究其磷酸化状态对神经干细胞分化的影响，发现DOK5在MAPK通路中起关键调控作用。
如需真实文献，建议通过PubMed或Google Scholar搜索"DOK5 antibody"或"DOK5 function"获取。
The DOK5 (Downstream of tyrosine kinase 5) antibody is a tool used to study the DOK5 protein, a member of the DOK family of adapter proteins involved in intracellular signaling. DOK proteins act as scaffolds, mediating interactions between receptor tyrosine kinases (RTKs) and downstream effectors. DOK5. specifically, is highly expressed in insulin-sensitive tissues (e.g., skeletal muscle, adipose tissue) and the nervous system. It plays a role in insulin signaling by binding to insulin receptor substrates (IRS) and modulating pathways linked to glucose metabolism, cell proliferation, and differentiation. Dysregulation of DOK5 has been implicated in metabolic disorders like diabetes and obesity, as well as in neurodevelopmental processes.
The DOK5 antibody enables researchers to detect and quantify DOK5 expression in various experimental models, aiding investigations into its functional roles. Studies using this antibody have revealed DOK5's interaction with RTKs such as TrkB (a neurotrophin receptor) and its involvement in neurite outgrowth and neuronal survival. Additionally, DOK5 is thought to compete with other DOK isoforms (e.g., DOK1-4) for signaling intermediates, influencing pathway specificity. Its tissue-specific expression and context-dependent interactions make DOK5 a key target for understanding metabolic and neurological diseases. The antibody is commonly applied in techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation to explore these mechanisms.
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