Rabbit Polyclonal DNAJC17 Antibody

The DNAJC17 antibody targets a protein encoded by the *DNAJC17* gene, a member of the J-domain protein (JDP) family, which regulates the activity of Hsp70 molecular chaperones. DNAJC17. also classified under the HSP40/DnaJ family, plays a role in protein folding, quality control, and cellular stress responses. Structurally, it contains a conserved J-domain that interacts with Hsp70. along with potential transmembrane or coiled-coil domains, suggesting localization to organelles like the endoplasmic reticulum or mitochondria. Its precise biological functions remain under investigation, though it is implicated in processes such as autophagy, apoptosis, and cellular signaling. Dysregulation of DNAJC17 has been tentatively linked to neurodegenerative diseases and cancers, though mechanistic insights are limited. Antibodies against DNAJC17 are primarily used in research to study its expression patterns, post-translational modifications, and subcellular distribution via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Commercial antibodies vary in specificity, often requiring validation through knockout controls due to potential cross-reactivity. Current challenges include elucidating its client proteins, tissue-specific roles, and disease-related pathways. Ongoing research aims to clarify its contributions to proteostasis and potential therapeutic relevance in protein-misfolding disorders.