| WB | 1/500-1/3000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger and SCAN domain-containing protein 16; Zinc finger protein 435; Zinc finger protein 392; ZSCAN16; ZNF392 |
| Entrez GeneID | 80345; |
| WB Predicted band size | 41kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human ZNF435. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZNF435抗体的示例参考文献(注：以下为模拟内容，实际文献需通过学术数据库查询)：
1. **文献名称**：*ZNF435在乳腺癌中的表达及临床意义*
**作者**：Smith J, et al.
**摘要**：通过免疫组化分析乳腺癌组织中ZNF435蛋白的表达水平，发现其高表达与患者预后不良显著相关，提示ZNF435可能作为乳腺癌的潜在生物标志物。
2. **文献名称**：*ZNF435在类风湿性关节炎患者中的异常表达及其意义*
**作者**：Zhang L, et al.
**摘要**：研究利用ZNF435抗体检测患者外周血单核细胞中的表达水平，发现其表达上调与炎症因子TNF-α和IL-6呈正相关，可能参与自身免疫反应调控。
3. **文献名称**：*ZNF435通过Wnt信号通路调控肿瘤细胞生长的分子机制*
**作者**：Johnson R, et al.
**摘要**：使用ZNF435抗体进行免疫共沉淀实验，证实其与β-catenin相互作用，调控Wnt通路活性，影响结直肠癌细胞的增殖和迁移。
4. **文献名称**：*ZNF435在表观遗传调控中的作用及其对基因表达的影响*
**作者**：Lee H, et al.
**摘要**：通过ChIP-seq技术结合ZNF435抗体，发现其与DNA甲基转移酶(DNMT3A)共定位，可能参与基因启动子区的甲基化调控及基因沉默。
**提示**：以上内容为模拟示例，建议通过PubMed、Google Scholar等平台检索最新文献，或查阅具体抗体供应商提供的引用文献。
The ZNF435 antibody is a research tool designed to detect and study the zinc finger protein 435 (ZNF435), a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein family. These proteins are characterized by tandem C2H2-type zinc finger motifs, which enable sequence-specific DNA binding, and the KRAB domain, which often mediates transcriptional repression via interactions with chromatin-modifying complexes. ZNF435 is implicated in transcriptional regulation, epigenetic silencing, and chromatin remodeling, though its precise biological functions remain under investigation.
Studies suggest ZNF435 may play roles in cellular differentiation, development, and disease pathways, including cancer. For example, aberrant expression or mutations in ZNF435 have been explored in tumorigenesis due to its potential influence on oncogene or tumor suppressor networks. The ZNF435 antibody is typically used in techniques like Western blotting, immunohistochemistry (IHC), or chromatin immunoprecipitation (ChIP) to analyze protein expression, localization, and DNA-binding activity.
Commercial ZNF435 antibodies are often raised in rabbits or mice using immunogenic peptides derived from conserved regions of the human protein. Validation data, including specificity (e.g., knockout-validated) and cross-reactivity, are critical for ensuring reliability. Researchers utilize this antibody to explore ZNF435's role in gene regulation, its interaction partners, and its relevance to diseases, contributing to broader insights into KRAB-ZFP functions in health and pathology.
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